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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E All Species: 40.3
Human Site: S53 Identified Species: 55.42
UniProt: P06730 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06730 NP_001959.1 217 25097 S53 W F F K N D K S K T W Q A N L
Chimpanzee Pan troglodytes XP_523824 217 24938 S53 W F F K N D K S K T S Q A N L
Rhesus Macaque Macaca mulatta XP_001092045 253 28850 S89 W F F K N D R S R A W Q D N L
Dog Lupus familis XP_544992 217 25075 S53 W F F K N D K S K T W Q A N L
Cat Felis silvestris
Mouse Mus musculus Q3UTA9 244 27967 S81 W F F K N D R S R A W Q D N L
Rat Rattus norvegicus P63074 217 25035 S53 W F F K N D K S K T W Q A N L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514651 236 27161 E62 S P T S S A N E S T T T P N P
Chicken Gallus gallus XP_420655 217 25026 S53 W F F K N D K S K T W Q A N L
Frog Xenopus laevis P48597 213 24616 S49 W F F K N D K S K T W Q A N L
Zebra Danio Brachydanio rerio Q9DFS6 215 24831 S51 W F F K N D K S K T W Q A N L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 S97 W Y L E N D R S K S W E D M Q
Honey Bee Apis mellifera XP_624290 213 24784 N49 W Y Y E P D R N K T W E E S Q
Nematode Worm Caenorhab. elegans O61955 248 27791 C54 R N K E W E D C L K M V S L F
Sea Urchin Strong. purpuratus NP_001091928 225 25645 A61 W F F K N D K A K S W T E N L
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 Q62 N P Q S K S K Q A A W G S S I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23252 235 26501 Q79 N P A V K S K Q T S W G S S L
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 S55 T K P A V D K S E S W S D L L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 59.2 99.5 N.A. 53.2 98.1 N.A. 71.6 92.1 88.4 82.9 N.A. 43.6 54.8 41.1 53.7
Protein Similarity: 100 98.6 69.1 99.5 N.A. 69.2 98.6 N.A. 74.1 94 94 92.6 N.A. 56.3 68.6 58.8 73.7
P-Site Identity: 100 93.3 73.3 100 N.A. 73.3 100 N.A. 13.3 100 100 100 N.A. 40 33.3 0 73.3
P-Site Similarity: 100 93.3 86.6 100 N.A. 86.6 100 N.A. 20 100 100 100 N.A. 73.3 80 20 86.6
Percent
Protein Identity: N.A. 42.2 N.A. 39.5 31.8 N.A.
Protein Similarity: N.A. 56.8 N.A. 54 55.3 N.A.
P-Site Identity: N.A. 13.3 N.A. 20 33.3 N.A.
P-Site Similarity: N.A. 33.3 N.A. 40 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 6 6 0 6 0 6 6 18 0 0 42 0 0 % A
% Cys: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 77 6 0 0 0 0 0 24 0 0 % D
% Glu: 0 0 0 18 0 6 0 6 6 0 0 12 12 0 0 % E
% Phe: 0 59 59 0 0 0 0 0 0 0 0 0 0 0 6 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % I
% Lys: 0 6 6 59 12 0 65 0 59 6 0 0 0 0 0 % K
% Leu: 0 0 6 0 0 0 0 0 6 0 0 0 0 12 71 % L
% Met: 0 0 0 0 0 0 0 0 0 0 6 0 0 6 0 % M
% Asn: 12 6 0 0 65 0 6 6 0 0 0 0 0 65 0 % N
% Pro: 0 18 6 0 6 0 0 0 0 0 0 0 6 0 6 % P
% Gln: 0 0 6 0 0 0 0 12 0 0 0 53 0 0 12 % Q
% Arg: 6 0 0 0 0 0 24 0 12 0 0 0 0 0 0 % R
% Ser: 6 0 0 12 6 12 0 65 6 24 6 6 18 18 0 % S
% Thr: 6 0 6 0 0 0 0 0 6 53 6 12 0 0 0 % T
% Val: 0 0 0 6 6 0 0 0 0 0 0 6 0 0 0 % V
% Trp: 71 0 0 0 6 0 0 0 0 0 83 0 0 0 0 % W
% Tyr: 0 12 6 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _