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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E All Species: 46.67
Human Site: S64 Identified Species: 64.17
UniProt: P06730 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06730 NP_001959.1 217 25097 S64 Q A N L R L I S K F D T V E D
Chimpanzee Pan troglodytes XP_523824 217 24938 S64 Q A N L W L I S K F D T V E D
Rhesus Macaque Macaca mulatta XP_001092045 253 28850 T100 Q D N L H L V T K V D S V E D
Dog Lupus familis XP_544992 217 25075 S64 Q A N L R L I S K F D T V E D
Cat Felis silvestris
Mouse Mus musculus Q3UTA9 244 27967 T92 Q D N L Q L V T K F N T V E D
Rat Rattus norvegicus P63074 217 25035 S64 Q A N L R L I S K F D T V E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514651 236 27161 A73 T P N P Q P P A E E E K T E T
Chicken Gallus gallus XP_420655 217 25026 S64 Q A N L R L I S K F D T V E D
Frog Xenopus laevis P48597 213 24616 S60 Q A N L R L I S K F D T V E D
Zebra Danio Brachydanio rerio Q9DFS6 215 24831 S62 Q A N L R L I S K F D T V E D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 T108 E D M Q N E I T S F D T V E D
Honey Bee Apis mellifera XP_624290 213 24784 T60 E E S Q R K V T S F D T A E D
Nematode Worm Caenorhab. elegans O61955 248 27791 E65 V S L F D T V E D F W S L Y N
Sea Urchin Strong. purpuratus NP_001091928 225 25645 T72 T E N L R T V T A F D T V E D
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 H73 G S S I R P I H T F S T V E E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23252 235 26501 F90 G S S L R P V F T F S T V E E
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 T66 S D L L R P V T S F Q T V E E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 59.2 99.5 N.A. 53.2 98.1 N.A. 71.6 92.1 88.4 82.9 N.A. 43.6 54.8 41.1 53.7
Protein Similarity: 100 98.6 69.1 99.5 N.A. 69.2 98.6 N.A. 74.1 94 94 92.6 N.A. 56.3 68.6 58.8 73.7
P-Site Identity: 100 93.3 60 100 N.A. 66.6 100 N.A. 13.3 100 100 100 N.A. 46.6 40 6.6 60
P-Site Similarity: 100 93.3 80 100 N.A. 93.3 100 N.A. 40 100 100 100 N.A. 60 66.6 40 73.3
Percent
Protein Identity: N.A. 42.2 N.A. 39.5 31.8 N.A.
Protein Similarity: N.A. 56.8 N.A. 54 55.3 N.A.
P-Site Identity: N.A. 40 N.A. 40 40 N.A.
P-Site Similarity: N.A. 66.6 N.A. 66.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 42 0 0 0 0 0 6 6 0 0 0 6 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 24 0 0 6 0 0 0 6 0 65 0 0 0 71 % D
% Glu: 12 12 0 0 0 6 0 6 6 6 6 0 0 95 18 % E
% Phe: 0 0 0 6 0 0 0 6 0 89 0 0 0 0 0 % F
% Gly: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 6 0 0 6 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 6 0 0 53 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 6 0 0 53 0 0 6 0 0 0 % K
% Leu: 0 0 12 71 0 53 0 0 0 0 0 0 6 0 0 % L
% Met: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 65 0 6 0 0 0 0 0 6 0 0 0 6 % N
% Pro: 0 6 0 6 0 24 6 0 0 0 0 0 0 0 0 % P
% Gln: 53 0 0 12 12 0 0 0 0 0 6 0 0 0 0 % Q
% Arg: 0 0 0 0 65 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 6 18 18 0 0 0 0 42 18 0 12 12 0 0 0 % S
% Thr: 12 0 0 0 0 12 0 36 12 0 0 83 6 0 6 % T
% Val: 6 0 0 0 0 0 42 0 0 6 0 0 83 0 0 % V
% Trp: 0 0 0 0 6 0 0 0 0 0 6 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _