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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E All Species: 14.55
Human Site: T11 Identified Species: 20
UniProt: P06730 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06730 NP_001959.1 217 25097 T11 V E P E T T P T P N P P T T E
Chimpanzee Pan troglodytes XP_523824 217 24938 T11 V E P E T T P T P N P P T T G
Rhesus Macaque Macaca mulatta XP_001092045 253 28850 G19 L V S E A K G G I Q E W K E E
Dog Lupus familis XP_544992 217 25075 T11 V E P E T T P T P N P P P T E
Cat Felis silvestris
Mouse Mus musculus Q3UTA9 244 27967 K39 G V Q A G E A K D L P G S L K
Rat Rattus norvegicus P63074 217 25035 T11 V E P E T T P T T N P P P A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514651 236 27161 C11 K F R R C S F C L P T P R D S
Chicken Gallus gallus XP_420655 217 25026 N11 V E P E T T P N P Q P S E E E
Frog Xenopus laevis P48597 213 24616 P11 V E P E N T N P Q S T E E E K
Zebra Danio Brachydanio rerio Q9DFS6 215 24831 N11 A E P E T S T N P S N S E E K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 K19 A N P K S M F K T S A P S T E
Honey Bee Apis mellifera XP_624290 213 24784 E11 S N T E E I E E V E R K E Q E
Nematode Worm Caenorhab. elegans O61955 248 27791 S12 V A E N K A L S A S G D V N A
Sea Urchin Strong. purpuratus NP_001091928 225 25645 G19 H E D I V K D G K G I K D L Q
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 R17 A S A G S R G R P A P E D D D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23252 235 26501 I20 E E A K P N S I E N P I D R Y
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 S15 K K F E E N V S V D D T T A T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 59.2 99.5 N.A. 53.2 98.1 N.A. 71.6 92.1 88.4 82.9 N.A. 43.6 54.8 41.1 53.7
Protein Similarity: 100 98.6 69.1 99.5 N.A. 69.2 98.6 N.A. 74.1 94 94 92.6 N.A. 56.3 68.6 58.8 73.7
P-Site Identity: 100 93.3 13.3 93.3 N.A. 6.6 80 N.A. 6.6 66.6 33.3 33.3 N.A. 26.6 13.3 6.6 6.6
P-Site Similarity: 100 93.3 20 93.3 N.A. 20 80 N.A. 13.3 66.6 46.6 53.3 N.A. 53.3 13.3 20 13.3
Percent
Protein Identity: N.A. 42.2 N.A. 39.5 31.8 N.A.
Protein Similarity: N.A. 56.8 N.A. 54 55.3 N.A.
P-Site Identity: N.A. 13.3 N.A. 20 13.3 N.A.
P-Site Similarity: N.A. 26.6 N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 18 6 12 6 6 6 6 0 6 6 6 0 0 12 6 % A
% Cys: 0 0 0 0 6 0 0 6 0 0 0 0 0 0 0 % C
% Asp: 0 0 6 0 0 0 6 0 6 6 6 6 18 12 6 % D
% Glu: 6 53 6 59 12 6 6 6 6 6 6 12 24 24 42 % E
% Phe: 0 6 6 0 0 0 12 0 0 0 0 0 0 0 0 % F
% Gly: 6 0 0 6 6 0 12 12 0 6 6 6 0 0 6 % G
% His: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 6 0 6 0 6 6 0 6 6 0 0 0 % I
% Lys: 12 6 0 12 6 12 0 12 6 0 0 12 6 0 18 % K
% Leu: 6 0 0 0 0 0 6 0 6 6 0 0 0 12 0 % L
% Met: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 12 0 6 6 12 6 12 0 30 6 0 0 6 0 % N
% Pro: 0 0 48 0 6 0 30 6 36 6 48 36 12 0 0 % P
% Gln: 0 0 6 0 0 0 0 0 6 12 0 0 0 6 6 % Q
% Arg: 0 0 6 6 0 6 0 6 0 0 6 0 6 6 0 % R
% Ser: 6 6 6 0 12 12 6 12 0 24 0 12 12 0 6 % S
% Thr: 0 0 6 0 36 36 6 24 12 0 12 6 18 24 6 % T
% Val: 42 12 0 0 6 0 6 0 12 0 0 0 6 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _