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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E
All Species:
21.82
Human Site:
T9
Identified Species:
30
UniProt:
P06730
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06730
NP_001959.1
217
25097
T9
A
T
V
E
P
E
T
T
P
T
P
N
P
P
T
Chimpanzee
Pan troglodytes
XP_523824
217
24938
T9
A
T
V
E
P
E
T
T
P
T
P
N
P
P
T
Rhesus Macaque
Macaca mulatta
XP_001092045
253
28850
K17
A
G
L
V
S
E
A
K
G
G
I
Q
E
W
K
Dog
Lupus familis
XP_544992
217
25075
T9
A
T
V
E
P
E
T
T
P
T
P
N
P
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTA9
244
27967
E37
A
E
G
V
Q
A
G
E
A
K
D
L
P
G
S
Rat
Rattus norvegicus
P63074
217
25035
T9
A
T
V
E
P
E
T
T
P
T
T
N
P
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514651
236
27161
S9
N
S
K
F
R
R
C
S
F
C
L
P
T
P
R
Chicken
Gallus gallus
XP_420655
217
25026
T9
A
T
V
E
P
E
T
T
P
N
P
Q
P
S
E
Frog
Xenopus laevis
P48597
213
24616
T9
A
A
V
E
P
E
N
T
N
P
Q
S
T
E
E
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
S9
A
T
A
E
P
E
T
S
T
N
P
S
N
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
M17
N
F
A
N
P
K
S
M
F
K
T
S
A
P
S
Honey Bee
Apis mellifera
XP_624290
213
24784
I9
A
T
S
N
T
E
E
I
E
E
V
E
R
K
E
Nematode Worm
Caenorhab. elegans
O61955
248
27791
A10
T
S
V
A
E
N
K
A
L
S
A
S
G
D
V
Sea Urchin
Strong. purpuratus
NP_001091928
225
25645
K17
P
L
H
E
D
I
V
K
D
G
K
G
I
K
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
R15
R
P
A
S
A
G
S
R
G
R
P
A
P
E
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23252
235
26501
N18
V
T
E
E
A
K
P
N
S
I
E
N
P
I
D
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
N13
V
S
K
K
F
E
E
N
V
S
V
D
D
T
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
59.2
99.5
N.A.
53.2
98.1
N.A.
71.6
92.1
88.4
82.9
N.A.
43.6
54.8
41.1
53.7
Protein Similarity:
100
98.6
69.1
99.5
N.A.
69.2
98.6
N.A.
74.1
94
94
92.6
N.A.
56.3
68.6
58.8
73.7
P-Site Identity:
100
100
13.3
93.3
N.A.
13.3
86.6
N.A.
6.6
73.3
40
46.6
N.A.
13.3
20
6.6
6.6
P-Site Similarity:
100
100
20
93.3
N.A.
20
86.6
N.A.
20
73.3
46.6
60
N.A.
40
20
26.6
6.6
Percent
Protein Identity:
N.A.
42.2
N.A.
39.5
31.8
N.A.
Protein Similarity:
N.A.
56.8
N.A.
54
55.3
N.A.
P-Site Identity:
N.A.
13.3
N.A.
26.6
13.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
33.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
59
6
18
6
12
6
6
6
6
0
6
6
6
0
0
% A
% Cys:
0
0
0
0
0
0
6
0
0
6
0
0
0
0
0
% C
% Asp:
0
0
0
0
6
0
0
0
6
0
6
6
6
6
18
% D
% Glu:
0
6
6
53
6
59
12
6
6
6
6
6
6
12
24
% E
% Phe:
0
6
0
6
6
0
0
0
12
0
0
0
0
0
0
% F
% Gly:
0
6
6
0
0
6
6
0
12
12
0
6
6
6
0
% G
% His:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
6
0
6
0
6
6
0
6
6
0
% I
% Lys:
0
0
12
6
0
12
6
12
0
12
6
0
0
12
6
% K
% Leu:
0
6
6
0
0
0
0
0
6
0
6
6
0
0
0
% L
% Met:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% M
% Asn:
12
0
0
12
0
6
6
12
6
12
0
30
6
0
0
% N
% Pro:
6
6
0
0
48
0
6
0
30
6
36
6
48
36
12
% P
% Gln:
0
0
0
0
6
0
0
0
0
0
6
12
0
0
0
% Q
% Arg:
6
0
0
0
6
6
0
6
0
6
0
0
6
0
6
% R
% Ser:
0
18
6
6
6
0
12
12
6
12
0
24
0
12
12
% S
% Thr:
6
48
0
0
6
0
36
36
6
24
12
0
12
6
18
% T
% Val:
12
0
42
12
0
0
6
0
6
0
12
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _