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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TH
All Species:
8.48
Human Site:
S350
Identified Species:
14.36
UniProt:
P07101
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07101
NP_000351.2
528
58600
S350
Q
Y
I
R
H
A
S
S
P
M
H
S
P
E
P
Chimpanzee
Pan troglodytes
XP_508221
618
67613
S440
Q
Y
I
R
H
A
S
S
P
M
H
S
P
E
P
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
L321
P
D
T
C
H
E
L
L
G
H
V
P
L
L
A
Dog
Lupus familis
XP_855547
495
55650
D325
P
M
H
S
P
E
P
D
C
C
H
E
L
L
G
Cat
Felis silvestris
Mouse
Mus musculus
P24529
498
55975
P325
A
S
S
P
M
H
S
P
E
P
D
C
C
H
E
Rat
Rattus norvegicus
P04177
498
55948
P325
A
S
S
P
M
H
S
P
E
P
D
C
C
H
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507458
568
65241
K390
Q
Y
I
R
H
A
S
K
P
M
Y
T
P
E
P
Chicken
Gallus gallus
P70080
445
51121
L276
P
D
T
C
H
E
L
L
G
H
V
P
L
L
A
Frog
Xenopus laevis
Q92142
481
55388
L312
P
D
T
C
H
E
L
L
G
H
V
P
L
L
A
Zebra Danio
Brachydanio rerio
NP_571224
489
55584
C320
M
H
S
P
E
P
D
C
V
H
E
L
L
G
H
Tiger Blowfish
Takifugu rubipres
NP_001027874
476
54285
H307
S
P
E
P
D
C
C
H
E
L
L
G
H
I
P
Fruit Fly
Dros. melanogaster
P18459
579
65977
S398
Q
Y
V
R
H
V
N
S
P
Y
H
T
P
E
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90925
457
52111
L288
P
D
I
C
H
E
L
L
G
H
V
P
L
F
A
Sea Urchin
Strong. purpuratus
XP_786206
522
59629
A344
Q
Y
V
R
H
S
S
A
P
M
H
T
P
E
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.1
43.1
84.2
N.A.
83.3
84.2
N.A.
45
43.7
42.9
65.1
51.8
43.1
N.A.
40.7
46.7
Protein Similarity:
100
83.6
60
87.5
N.A.
86.9
87.8
N.A.
60.3
58.7
60.2
77.6
66.8
61.4
N.A.
59.2
65.7
P-Site Identity:
100
100
6.6
6.6
N.A.
6.6
6.6
N.A.
80
6.6
6.6
0
6.6
66.6
N.A.
13.3
73.3
P-Site Similarity:
100
100
6.6
6.6
N.A.
6.6
6.6
N.A.
93.3
6.6
6.6
6.6
13.3
86.6
N.A.
13.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
0
0
22
0
8
0
0
0
0
0
0
29
% A
% Cys:
0
0
0
29
0
8
8
8
8
8
0
15
15
0
0
% C
% Asp:
0
29
0
0
8
0
8
8
0
0
15
0
0
0
0
% D
% Glu:
0
0
8
0
8
36
0
0
22
0
8
8
0
36
15
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
29
0
0
8
0
8
8
% G
% His:
0
8
8
0
65
15
0
8
0
36
36
0
8
15
8
% H
% Ile:
0
0
29
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
29
29
0
8
8
8
43
29
0
% L
% Met:
8
8
0
0
15
0
0
0
0
29
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
36
8
0
29
8
8
8
15
36
15
0
29
36
0
43
% P
% Gln:
36
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
36
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
15
22
8
0
8
43
22
0
0
0
15
0
0
0
% S
% Thr:
0
0
22
0
0
0
0
0
0
0
0
22
0
0
0
% T
% Val:
0
0
15
0
0
8
0
0
8
0
29
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
36
0
0
0
0
0
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _