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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TH
All Species:
23.64
Human Site:
S435
Identified Species:
40
UniProt:
P07101
Number Species:
13
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07101
NP_000351.2
528
58600
S435
G
E
L
L
H
C
L
S
E
E
P
E
I
R
A
Chimpanzee
Pan troglodytes
XP_508221
618
67613
S525
G
E
L
L
H
C
L
S
E
E
P
E
I
R
A
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
D401
K
A
C
V
K
A
F
D
P
K
T
T
C
L
Q
Dog
Lupus familis
XP_855547
495
55650
P405
L
H
S
L
S
E
E
P
E
I
R
A
F
D
P
Cat
Felis silvestris
Mouse
Mus musculus
P24529
498
55975
S405
G
E
L
L
H
S
L
S
E
E
P
E
V
R
A
Rat
Rattus norvegicus
P04177
498
55948
S405
G
E
L
L
H
S
L
S
E
E
P
E
V
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507458
568
65241
S475
G
E
L
Q
Y
C
L
S
E
K
P
Q
L
L
P
Chicken
Gallus gallus
P70080
445
51121
D356
S
A
K
V
K
P
F
D
P
K
V
T
C
K
Q
Frog
Xenopus laevis
Q92142
481
55388
D392
N
A
K
V
K
P
F
D
P
M
V
T
C
N
Q
Zebra Danio
Brachydanio rerio
NP_571224
489
55584
E400
H
S
L
S
D
E
P
E
R
R
E
F
D
P
D
Tiger Blowfish
Takifugu rubipres
NP_001027874
476
54285
K387
L
S
N
E
P
E
Y
K
P
F
I
P
E
E
T
Fruit Fly
Dros. melanogaster
P18459
579
65977
S483
G
E
L
L
H
A
I
S
D
K
C
E
H
R
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90925
457
52111
D368
K
P
E
V
V
D
F
D
P
A
V
C
C
V
T
Sea Urchin
Strong. purpuratus
XP_786206
522
59629
S429
G
E
L
Q
Y
A
L
S
D
K
P
E
H
R
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.1
43.1
84.2
N.A.
83.3
84.2
N.A.
45
43.7
42.9
65.1
51.8
43.1
N.A.
40.7
46.7
Protein Similarity:
100
83.6
60
87.5
N.A.
86.9
87.8
N.A.
60.3
58.7
60.2
77.6
66.8
61.4
N.A.
59.2
65.7
P-Site Identity:
100
100
0
13.3
N.A.
86.6
86.6
N.A.
53.3
0
0
6.6
0
60
N.A.
0
53.3
P-Site Similarity:
100
100
13.3
13.3
N.A.
93.3
93.3
N.A.
80
20
6.6
6.6
0
80
N.A.
6.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
22
0
0
0
22
0
0
0
8
0
8
0
0
36
% A
% Cys:
0
0
8
0
0
22
0
0
0
0
8
8
29
0
0
% C
% Asp:
0
0
0
0
8
8
0
29
15
0
0
0
8
8
8
% D
% Glu:
0
50
8
8
0
22
8
8
43
29
8
43
8
8
0
% E
% Phe:
0
0
0
0
0
0
29
0
0
8
0
8
8
0
0
% F
% Gly:
50
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
8
8
0
0
36
0
0
0
0
0
0
0
15
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
8
8
0
15
0
0
% I
% Lys:
15
0
15
0
22
0
0
8
0
36
0
0
0
8
0
% K
% Leu:
15
0
58
43
0
0
43
0
0
0
0
0
8
15
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
8
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
8
0
0
8
15
8
8
36
0
43
8
0
8
22
% P
% Gln:
0
0
0
15
0
0
0
0
0
0
0
8
0
0
22
% Q
% Arg:
0
0
0
0
0
0
0
0
8
8
8
0
0
43
0
% R
% Ser:
8
15
8
8
8
15
0
50
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
8
22
0
0
15
% T
% Val:
0
0
0
29
8
0
0
0
0
0
22
0
15
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
15
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _