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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TH
All Species:
29.09
Human Site:
Y462
Identified Species:
49.23
UniProt:
P07101
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07101
NP_000351.2
528
58600
Y462
D
Q
T
Y
Q
S
V
Y
F
V
S
E
S
F
S
Chimpanzee
Pan troglodytes
XP_508221
618
67613
Y552
D
Q
T
Y
Q
S
V
Y
F
V
S
E
S
F
S
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
F425
A
Y
F
V
S
E
S
F
E
E
A
K
E
K
M
Dog
Lupus familis
XP_855547
495
55650
Y429
D
Q
T
Y
Q
S
V
Y
F
V
S
E
S
F
S
Cat
Felis silvestris
Mouse
Mus musculus
P24529
498
55975
Y432
D
Q
T
Y
Q
P
V
Y
F
V
S
E
S
F
S
Rat
Rattus norvegicus
P04177
498
55948
Y432
D
Q
T
Y
Q
P
V
Y
F
V
S
E
S
F
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507458
568
65241
Y502
I
T
E
F
Q
P
I
Y
F
V
A
E
S
F
K
Chicken
Gallus gallus
P70080
445
51121
F380
V
Y
F
V
S
E
S
F
E
E
A
K
E
K
M
Frog
Xenopus laevis
Q92142
481
55388
F416
L
Y
F
V
S
E
S
F
E
E
A
K
E
K
M
Zebra Danio
Brachydanio rerio
NP_571224
489
55584
F424
Q
T
Y
Q
P
V
Y
F
V
S
E
S
F
V
D
Tiger Blowfish
Takifugu rubipres
NP_001027874
476
54285
S411
Y
Q
P
V
Y
F
V
S
E
S
F
E
D
A
K
Fruit Fly
Dros. melanogaster
P18459
579
65977
Y510
D
Q
E
Y
Q
P
I
Y
Y
V
A
E
S
F
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90925
457
52111
F392
K
Y
F
L
A
E
S
F
A
S
A
K
N
K
L
Sea Urchin
Strong. purpuratus
XP_786206
522
59629
Y456
D
K
N
Y
Q
P
I
Y
F
V
A
D
S
F
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.1
43.1
84.2
N.A.
83.3
84.2
N.A.
45
43.7
42.9
65.1
51.8
43.1
N.A.
40.7
46.7
Protein Similarity:
100
83.6
60
87.5
N.A.
86.9
87.8
N.A.
60.3
58.7
60.2
77.6
66.8
61.4
N.A.
59.2
65.7
P-Site Identity:
100
100
0
100
N.A.
93.3
86.6
N.A.
46.6
0
0
0
20
60
N.A.
0
60
P-Site Similarity:
100
100
20
100
N.A.
93.3
93.3
N.A.
66.6
20
20
6.6
20
80
N.A.
26.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
8
0
50
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
50
0
0
0
0
0
0
0
0
0
0
8
8
0
8
% D
% Glu:
0
0
15
0
0
29
0
0
29
22
8
58
22
0
8
% E
% Phe:
0
0
29
8
0
8
0
36
50
0
8
0
8
58
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
22
0
0
0
0
0
0
0
0
% I
% Lys:
8
8
0
0
0
0
0
0
0
0
0
29
0
29
15
% K
% Leu:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
22
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
8
% N
% Pro:
0
0
8
0
8
36
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
50
0
8
58
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
22
22
29
8
0
22
36
8
58
0
36
% S
% Thr:
0
15
36
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
0
29
0
8
43
0
8
58
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
29
8
50
8
0
8
58
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _