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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DBI All Species: 45.15
Human Site: T42 Identified Species: 76.41
UniProt: P07108 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07108 NP_001073331.1 87 10044 T42 A T V G D I N T E R P G M L D
Chimpanzee Pan troglodytes XP_001156427 104 11890 T59 A T V G D I N T E R P G M L D
Rhesus Macaque Macaca mulatta XP_001103096 102 11963 T42 A T V G D V N T E R P R M L D
Dog Lupus familis XP_849337 87 9960 T42 A T V G D I N T E R P G L L D
Cat Felis silvestris
Mouse Mus musculus P31786 87 9982 T42 A T V G D V N T D R P G L L D
Rat Rattus norvegicus P11030 87 10009 T42 A T V G D V N T D R P G L L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9PRL8 86 9626 T41 A T V G D V N T D R P G M L D
Frog Xenopus laevis NP_001085947 85 9634 N41 Q A T V G D V N T D R P G M L
Zebra Danio Brachydanio rerio NP_955902 87 9643 T42 A T V G D V N T A R P G M L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P42281 86 9538 T42 A S V G D N D T A K P G L L D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O01805 86 9355 T41 G T V G D N T T D K P G M F D
Sea Urchin Strong. purpuratus XP_784299 87 9491 T41 V T V G D C N T D R P G M L D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P57752 92 10367 T43 A K F G P V D T S R P G M F S
Baker's Yeast Sacchar. cerevisiae P31787 87 10043 K42 A T V G D N D K E K P G I F N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.6 76.4 85 N.A. 78.1 78.1 N.A. N.A. 75.8 73.5 79.3 N.A. 50.5 N.A. 54 59.7
Protein Similarity: 100 83.6 83.3 96.5 N.A. 91.9 93 N.A. N.A. 88.5 81.6 87.3 N.A. 66.6 N.A. 71.2 70.1
P-Site Identity: 100 100 86.6 93.3 N.A. 80 80 N.A. N.A. 86.6 0 86.6 N.A. 60 N.A. 60 80
P-Site Similarity: 100 100 93.3 100 N.A. 100 100 N.A. N.A. 100 6.6 93.3 N.A. 86.6 N.A. 73.3 86.6
Percent
Protein Identity: N.A. N.A. N.A. 44.5 48.2 N.A.
Protein Similarity: N.A. N.A. N.A. 61.9 64.3 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 79 8 0 0 0 0 0 0 15 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 86 8 22 0 36 8 0 0 0 0 79 % D
% Glu: 0 0 0 0 0 0 0 0 36 0 0 0 0 0 0 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 0 22 0 % F
% Gly: 8 0 0 93 8 0 0 0 0 0 0 86 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 22 0 0 0 0 0 0 8 0 0 % I
% Lys: 0 8 0 0 0 0 0 8 0 22 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 29 72 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 58 8 0 % M
% Asn: 0 0 0 0 0 22 65 8 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 0 8 0 0 0 0 0 93 8 0 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 72 8 8 0 0 0 % R
% Ser: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 8 % S
% Thr: 0 79 8 0 0 0 8 86 8 0 0 0 0 0 0 % T
% Val: 8 0 86 8 0 43 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _