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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: P4HB All Species: 43.94
Human Site: Y99 Identified Species: 74.36
UniProt: P07237 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07237 NP_000909.2 508 57116 Y99 Q Q Y G V R G Y P T I K F F R
Chimpanzee Pan troglodytes XP_001164396 508 57114 Y99 Q Q Y G V R G Y P T I K F F R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540488 510 57398 Y101 H Q Y G V R G Y P T I K F F K
Cat Felis silvestris
Mouse Mus musculus P09103 509 57125 Y101 Q Q Y G V R G Y P T I K F F K
Rat Rattus norvegicus P04785 509 56933 Y101 Q Q Y G V R G Y P T I K F F K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517226 512 56706 Y103 Q Q Y G V R G Y P T I K F F K
Chicken Gallus gallus P12244 508 56874 Y98 Q Q Y G V R A Y P T I K F F K
Frog Xenopus laevis NP_001079815 505 56621 Y99 Q E F G V R G Y P T I K F F K
Zebra Danio Brachydanio rerio NP_998529 509 56615 Y97 Q E F G V R G Y P T I K F F K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54399 496 55763 Y102 E Q Y A V R G Y P T L K F F R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17770 493 55134 Y98 S K F E V R G Y P T L K L F R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays P52588 513 57078 Q109 L A T K Y E I Q G F P T I K I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XI01 501 55583 Q105 F A T Q Y E V Q G F P T I K I
Baker's Yeast Sacchar. cerevisiae P17967 522 58209 S107 H N I P G F P S L K I F K N S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 93.1 N.A. 93.7 93.9 N.A. 88.4 83.8 76.3 72.5 N.A. 54.1 N.A. 56.5 N.A.
Protein Similarity: 100 99.8 N.A. 96 N.A. 96.2 96.2 N.A. 94.3 91.7 86 85.6 N.A. 71.6 N.A. 74.2 N.A.
P-Site Identity: 100 100 N.A. 86.6 N.A. 93.3 93.3 N.A. 93.3 86.6 80 80 N.A. 80 N.A. 60 N.A.
P-Site Similarity: 100 100 N.A. 93.3 N.A. 100 100 N.A. 100 93.3 100 100 N.A. 93.3 N.A. 80 N.A.
Percent
Protein Identity: N.A. 36.4 N.A. 36.4 30.2 N.A.
Protein Similarity: N.A. 54.9 N.A. 58.2 49.6 N.A.
P-Site Identity: N.A. 0 N.A. 0 6.6 N.A.
P-Site Similarity: N.A. 0 N.A. 0 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 0 8 0 0 8 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 15 0 8 0 15 0 0 0 0 0 0 0 0 0 % E
% Phe: 8 0 22 0 0 8 0 0 0 15 0 8 72 79 0 % F
% Gly: 0 0 0 65 8 0 72 0 15 0 0 0 0 0 0 % G
% His: 15 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 8 0 0 0 72 0 15 0 15 % I
% Lys: 0 8 0 8 0 0 0 0 0 8 0 79 8 15 50 % K
% Leu: 8 0 0 0 0 0 0 0 8 0 15 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 0 0 8 0 0 8 0 79 0 15 0 0 0 0 % P
% Gln: 58 58 0 8 0 0 0 15 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 79 0 0 0 0 0 0 0 0 29 % R
% Ser: 8 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % S
% Thr: 0 0 15 0 0 0 0 0 0 79 0 15 0 0 0 % T
% Val: 0 0 0 0 79 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 58 0 15 0 0 79 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _