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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSD
All Species:
33.33
Human Site:
Y394
Identified Species:
66.67
UniProt:
P07339
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07339
NP_001900.1
412
44552
Y394
D
V
F
I
G
R
Y
Y
T
V
F
D
R
D
N
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
P11489
388
41678
D376
R
Q
Y
F
T
V
F
D
R
A
N
N
Q
V
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P18242
410
44935
Y392
D
V
F
I
G
S
Y
Y
T
V
F
D
R
D
N
Rat
Rattus norvegicus
P24268
407
44662
Y389
D
V
F
I
G
C
Y
Y
T
V
F
D
R
E
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q05744
398
43280
Y382
D
V
F
I
G
P
Y
Y
T
V
F
D
R
D
N
Frog
Xenopus laevis
Q805F3
397
42889
Y372
D
V
F
I
G
Q
Y
Y
S
V
F
D
R
G
N
Zebra Danio
Brachydanio rerio
NP_571785
399
43486
Y381
D
V
F
I
G
Q
Y
Y
T
V
F
D
R
E
N
Tiger Blowfish
Takifugu rubipres
NP_001072052
396
43134
Y380
D
V
F
I
G
Q
Y
Y
T
V
F
D
R
D
N
Fruit Fly
Dros. melanogaster
NP_652013
392
42454
Y376
D
V
F
I
G
K
Y
Y
T
E
F
D
M
G
N
Honey Bee
Apis mellifera
XP_392857
385
42204
N376
Y
T
E
F
D
M
G
N
N
R
V
G
F
A
T
Nematode Worm
Caenorhab. elegans
P55956
398
43395
Y379
D
V
F
I
G
R
F
Y
S
V
F
D
H
G
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q01294
396
42914
D383
R
K
Y
Y
S
I
Y
D
L
G
A
D
T
V
G
Conservation
Percent
Protein Identity:
100
N.A.
45.3
N.A.
N.A.
80.8
81.8
N.A.
N.A.
67.2
45.3
64
66.7
52.9
55.3
44.9
N.A.
Protein Similarity:
100
N.A.
60.4
N.A.
N.A.
89
89.3
N.A.
N.A.
79.6
64.5
77.4
79.3
68.9
68.9
59.9
N.A.
P-Site Identity:
100
N.A.
0
N.A.
N.A.
93.3
80
N.A.
N.A.
93.3
80
86.6
93.3
73.3
0
73.3
N.A.
P-Site Similarity:
100
N.A.
26.6
N.A.
N.A.
93.3
86.6
N.A.
N.A.
93.3
93.3
100
100
80
0
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
41.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
58.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
9
9
0
0
9
0
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
75
0
0
0
9
0
0
17
0
0
0
84
0
34
0
% D
% Glu:
0
0
9
0
0
0
0
0
0
9
0
0
0
17
0
% E
% Phe:
0
0
75
17
0
0
17
0
0
0
75
0
9
0
0
% F
% Gly:
0
0
0
0
75
0
9
0
0
9
0
9
0
25
17
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
0
75
0
9
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
9
0
0
0
9
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
0
0
0
0
0
9
9
0
9
9
0
0
67
% N
% Pro:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
0
0
25
0
0
0
0
0
0
9
0
0
% Q
% Arg:
17
0
0
0
0
17
0
0
9
9
0
0
59
0
0
% R
% Ser:
0
0
0
0
9
9
0
0
17
0
0
0
0
0
0
% S
% Thr:
0
9
0
0
9
0
0
0
59
0
0
0
9
0
9
% T
% Val:
0
75
0
0
0
9
0
0
0
67
9
0
0
17
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
17
9
0
0
75
75
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _