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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEXB
All Species:
16.67
Human Site:
S144
Identified Species:
30.56
UniProt:
P07686
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07686
NP_000512.1
556
63111
S144
C
D
A
F
P
N
I
S
S
D
E
S
Y
T
L
Chimpanzee
Pan troglodytes
XP_001150632
556
63122
S144
C
D
A
F
P
N
I
S
S
D
E
S
Y
T
L
Rhesus Macaque
Macaca mulatta
XP_001103055
556
62884
S144
C
D
A
F
P
N
I
S
S
D
E
S
Y
T
L
Dog
Lupus familis
XP_535275
570
64111
T161
C
D
L
Y
P
N
V
T
S
D
E
S
Y
S
L
Cat
Felis silvestris
Mouse
Mus musculus
P20060
536
61097
L131
S
D
E
T
Y
S
L
L
V
Q
E
P
V
A
V
Rat
Rattus norvegicus
Q6AXR4
537
61509
V131
D
E
S
Y
S
L
L
V
Q
E
P
V
A
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513475
574
64498
S159
E
C
D
A
Y
P
S
S
T
S
D
E
S
Y
Q
Chicken
Gallus gallus
NP_001025561
526
58930
W132
L
L
Y
A
D
A
V
W
G
A
L
R
G
L
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001108317
541
61514
S134
T
D
E
S
Y
S
L
S
V
D
E
T
S
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8WSF3
660
75468
V162
G
S
S
S
E
P
T
V
S
E
S
S
S
K
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22492
555
64361
G136
I
N
A
Q
T
V
W
G
A
L
R
A
M
E
S
Sea Urchin
Strong. purpuratus
XP_799340
543
61806
D133
D
Y
P
Q
L
E
S
D
E
S
Y
S
L
T
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001142218
433
49746
V51
L
E
T
F
S
Q
L
V
W
K
S
A
E
G
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
95.8
63.6
N.A.
73.3
71.9
N.A.
64.4
54.3
N.A.
59.7
N.A.
30.1
N.A.
40.8
49.6
Protein Similarity:
100
99.4
97.3
74
N.A.
85.2
83.6
N.A.
77.3
69.5
N.A.
72.1
N.A.
43.7
N.A.
57.9
65.6
P-Site Identity:
100
100
100
66.6
N.A.
13.3
6.6
N.A.
6.6
0
N.A.
26.6
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
33.3
40
N.A.
20
6.6
N.A.
53.3
N.A.
26.6
N.A.
26.6
20
Percent
Protein Identity:
N.A.
48.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
60.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
31
16
0
8
0
0
8
8
0
16
8
16
0
% A
% Cys:
31
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
47
8
0
8
0
0
8
0
39
8
0
0
0
0
% D
% Glu:
8
16
16
0
8
8
0
0
8
16
47
8
8
8
8
% E
% Phe:
0
0
0
31
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
8
8
0
0
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
24
0
0
0
0
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% K
% Leu:
16
8
8
0
8
8
31
8
0
8
8
0
8
16
39
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
0
0
0
31
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
31
16
0
0
0
0
8
8
0
0
0
% P
% Gln:
0
0
0
16
0
8
0
0
8
8
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% R
% Ser:
8
8
16
16
16
16
16
39
39
16
16
47
24
8
16
% S
% Thr:
8
0
8
8
8
0
8
8
8
0
0
8
0
31
8
% T
% Val:
0
0
0
0
0
8
16
24
16
0
0
8
8
0
16
% V
% Trp:
0
0
0
0
0
0
8
8
8
0
0
0
0
0
0
% W
% Tyr:
0
8
8
16
24
0
0
0
0
0
8
0
31
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _