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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HEXB All Species: 34.55
Human Site: S385 Identified Species: 63.33
UniProt: P07686 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07686 NP_000512.1 556 63111 S385 T D F K K L E S F Y I Q K V L
Chimpanzee Pan troglodytes XP_001150632 556 63122 S385 T D F K K L E S F Y I Q K V L
Rhesus Macaque Macaca mulatta XP_001103055 556 62884 S385 K D F K K L E S F Y I Q K V L
Dog Lupus familis XP_535275 570 64111 S402 E D Y K K L E S F Y V Q K V L
Cat Felis silvestris
Mouse Mus musculus P20060 536 61097 S364 S D F R R L E S F Y I K K I L
Rat Rattus norvegicus Q6AXR4 537 61509 S363 N N F R R L E S F Y I K K I L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513475 574 64498 S401 E N Y N K L E S Y Y I Q K L L
Chicken Gallus gallus NP_001025561 526 58930 S352 E D Y T K L E S Y Y I Q R L L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001108317 541 61514 S368 T D Y S K L E S F Y I Q R L L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8WSF3 660 75468 C461 T D L R G L W C D F M L Q A M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22492 555 64361 N358 N D T V L L E N Y F F E K L Y
Sea Urchin Strong. purpuratus XP_799340 543 61806 Q371 K N Y S M L E Q Y Y E Q R L L
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001142218 433 49746 Y270 L L D I V S D Y D K G Y V V W
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 95.8 63.6 N.A. 73.3 71.9 N.A. 64.4 54.3 N.A. 59.7 N.A. 30.1 N.A. 40.8 49.6
Protein Similarity: 100 99.4 97.3 74 N.A. 85.2 83.6 N.A. 77.3 69.5 N.A. 72.1 N.A. 43.7 N.A. 57.9 65.6
P-Site Identity: 100 100 93.3 80 N.A. 66.6 60 N.A. 60 60 N.A. 73.3 N.A. 20 N.A. 26.6 33.3
P-Site Similarity: 100 100 93.3 93.3 N.A. 100 93.3 N.A. 86.6 86.6 N.A. 93.3 N.A. 53.3 N.A. 60 66.6
Percent
Protein Identity: N.A. 48.5 N.A. N.A. N.A. N.A.
Protein Similarity: N.A. 60.9 N.A. N.A. N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. 13.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 70 8 0 0 0 8 0 16 0 0 0 0 0 0 % D
% Glu: 24 0 0 0 0 0 85 0 0 0 8 8 0 0 0 % E
% Phe: 0 0 39 0 0 0 0 0 54 16 8 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 62 0 0 16 0 % I
% Lys: 16 0 0 31 54 0 0 0 0 8 0 16 62 0 0 % K
% Leu: 8 8 8 0 8 93 0 0 0 0 0 8 0 39 77 % L
% Met: 0 0 0 0 8 0 0 0 0 0 8 0 0 0 8 % M
% Asn: 16 24 0 8 0 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 0 0 62 8 0 0 % Q
% Arg: 0 0 0 24 16 0 0 0 0 0 0 0 24 0 0 % R
% Ser: 8 0 0 16 0 8 0 70 0 0 0 0 0 0 0 % S
% Thr: 31 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 8 8 0 0 0 0 0 8 0 8 39 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 39 0 0 0 0 8 31 77 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _