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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEXB
All Species:
5.45
Human Site:
S47
Identified Species:
10
UniProt:
P07686
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07686
NP_000512.1
556
63111
S47
A
E
A
A
R
A
P
S
V
S
A
K
P
G
P
Chimpanzee
Pan troglodytes
XP_001150632
556
63122
S47
A
E
A
A
R
A
P
S
F
S
A
K
P
G
P
Rhesus Macaque
Macaca mulatta
XP_001103055
556
62884
G47
A
E
A
T
R
A
P
G
V
S
A
A
R
G
P
Dog
Lupus familis
XP_535275
570
64111
L64
T
H
H
A
R
R
A
L
E
A
P
E
R
P
A
Cat
Felis silvestris
Mouse
Mus musculus
P20060
536
61097
A34
A
P
A
R
L
Q
P
A
L
W
P
F
P
R
S
Rat
Rattus norvegicus
Q6AXR4
537
61509
L34
P
F
G
L
Q
P
A
L
W
P
M
P
R
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513475
574
64498
S62
P
L
G
S
S
C
R
S
F
R
G
P
A
G
P
Chicken
Gallus gallus
NP_001025561
526
58930
A35
Q
L
Q
R
S
P
P
A
P
A
R
C
P
L
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001108317
541
61514
L37
K
E
L
D
E
I
S
L
W
P
L
P
Q
K
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8WSF3
660
75468
C65
E
K
S
W
T
Y
K
C
E
N
D
R
C
M
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22492
555
64361
K39
G
G
V
W
P
L
P
K
K
I
V
Y
G
S
K
Sea Urchin
Strong. purpuratus
XP_799340
543
61806
A36
G
V
P
P
P
L
K
A
V
T
S
S
S
Q
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001142218
433
49746
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
95.8
63.6
N.A.
73.3
71.9
N.A.
64.4
54.3
N.A.
59.7
N.A.
30.1
N.A.
40.8
49.6
Protein Similarity:
100
99.4
97.3
74
N.A.
85.2
83.6
N.A.
77.3
69.5
N.A.
72.1
N.A.
43.7
N.A.
57.9
65.6
P-Site Identity:
100
93.3
73.3
13.3
N.A.
26.6
0
N.A.
20
20
N.A.
6.6
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
93.3
73.3
26.6
N.A.
40
6.6
N.A.
26.6
33.3
N.A.
6.6
N.A.
26.6
N.A.
6.6
26.6
Percent
Protein Identity:
N.A.
48.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
60.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
0
31
24
0
24
16
24
0
16
24
8
8
0
8
% A
% Cys:
0
0
0
0
0
8
0
8
0
0
0
8
8
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% D
% Glu:
8
31
0
0
8
0
0
0
16
0
0
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
16
0
0
8
0
0
0
% F
% Gly:
16
8
16
0
0
0
0
8
0
0
8
0
8
31
8
% G
% His:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% I
% Lys:
8
8
0
0
0
0
16
8
8
0
0
16
0
8
8
% K
% Leu:
0
16
8
8
8
16
0
24
8
0
8
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
16
8
8
8
16
16
47
0
8
16
16
24
31
8
39
% P
% Gln:
8
0
8
0
8
8
0
0
0
0
0
0
8
8
0
% Q
% Arg:
0
0
0
16
31
8
8
0
0
8
8
8
24
8
8
% R
% Ser:
0
0
8
8
16
0
8
24
0
24
8
8
8
16
8
% S
% Thr:
8
0
0
8
8
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
8
8
0
0
0
0
0
24
0
8
0
0
0
8
% V
% Trp:
0
0
0
16
0
0
0
0
16
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _