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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEXB
All Species:
30.61
Human Site:
Y277
Identified Species:
56.11
UniProt:
P07686
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07686
NP_000512.1
556
63111
Y277
D
V
R
M
V
I
E
Y
A
R
L
R
G
I
R
Chimpanzee
Pan troglodytes
XP_001150632
556
63122
Y277
D
V
R
M
V
I
E
Y
A
R
L
R
G
I
R
Rhesus Macaque
Macaca mulatta
XP_001103055
556
62884
Y277
D
V
R
M
V
I
E
Y
A
R
L
R
G
I
R
Dog
Lupus familis
XP_535275
570
64111
Y294
D
V
H
T
V
I
E
Y
A
R
L
R
G
I
R
Cat
Felis silvestris
Mouse
Mus musculus
P20060
536
61097
Y256
D
V
R
M
V
L
E
Y
A
R
L
R
G
I
R
Rat
Rattus norvegicus
Q6AXR4
537
61509
Y255
D
I
H
M
V
L
E
Y
A
R
L
R
G
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513475
574
64498
Y293
D
V
R
L
V
I
E
Y
A
R
L
R
G
I
R
Chicken
Gallus gallus
NP_001025561
526
58930
I250
E
Y
A
R
L
R
G
I
R
V
I
A
E
F
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001108317
541
61514
F260
D
V
K
M
V
I
E
F
A
R
M
R
G
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8WSF3
660
75468
F353
D
V
R
E
V
A
E
F
A
K
I
Y
G
V
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22492
555
64361
I256
R
L
R
G
I
R
V
I
P
E
F
D
L
P
G
Sea Urchin
Strong. purpuratus
XP_799340
543
61806
Y264
N
V
K
A
V
I
E
Y
A
R
L
R
G
I
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001142218
433
49746
L169
F
D
T
P
G
H
T
L
S
W
G
A
G
V
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
95.8
63.6
N.A.
73.3
71.9
N.A.
64.4
54.3
N.A.
59.7
N.A.
30.1
N.A.
40.8
49.6
Protein Similarity:
100
99.4
97.3
74
N.A.
85.2
83.6
N.A.
77.3
69.5
N.A.
72.1
N.A.
43.7
N.A.
57.9
65.6
P-Site Identity:
100
100
100
86.6
N.A.
93.3
80
N.A.
93.3
0
N.A.
80
N.A.
46.6
N.A.
6.6
80
P-Site Similarity:
100
100
100
86.6
N.A.
100
93.3
N.A.
100
20
N.A.
100
N.A.
80
N.A.
20
93.3
Percent
Protein Identity:
N.A.
48.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
60.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
8
0
0
77
0
0
16
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
70
8
0
0
0
0
0
0
0
0
0
8
0
0
8
% D
% Glu:
8
0
0
8
0
0
77
0
0
8
0
0
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
16
0
0
8
0
0
8
0
% F
% Gly:
0
0
0
8
8
0
8
0
0
0
8
0
85
0
8
% G
% His:
0
0
16
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
8
54
0
16
0
0
16
0
0
70
0
% I
% Lys:
0
0
16
0
0
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
8
0
8
8
16
0
8
0
0
62
0
8
0
0
% L
% Met:
0
0
0
47
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
8
0
0
0
0
8
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
8
0
54
8
0
16
0
0
8
70
0
70
0
0
70
% R
% Ser:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% S
% Thr:
0
0
8
8
0
0
8
0
0
0
0
0
0
0
0
% T
% Val:
0
70
0
0
77
0
8
0
0
8
0
0
0
16
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
62
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _