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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEXB
All Species:
36.97
Human Site:
Y464
Identified Species:
67.78
UniProt:
P07686
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07686
NP_000512.1
556
63111
Y464
G
Q
D
W
R
K
Y
Y
K
V
E
P
L
D
F
Chimpanzee
Pan troglodytes
XP_001150632
556
63122
Y464
G
Q
D
W
R
K
Y
Y
K
V
E
P
L
D
F
Rhesus Macaque
Macaca mulatta
XP_001103055
556
62884
Y464
G
Q
D
W
R
K
Y
Y
K
V
E
P
L
D
F
Dog
Lupus familis
XP_535275
570
64111
Y481
G
Q
D
W
K
G
Y
Y
K
V
D
P
L
D
F
Cat
Felis silvestris
Mouse
Mus musculus
P20060
536
61097
Y443
G
Q
D
W
K
N
Y
Y
K
V
E
P
L
N
F
Rat
Rattus norvegicus
Q6AXR4
537
61509
Y442
G
Q
D
W
R
N
Y
Y
K
A
E
P
L
N
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513475
574
64498
Y480
G
Q
D
W
K
K
Y
Y
S
V
E
P
L
N
F
Chicken
Gallus gallus
NP_001025561
526
58930
Y432
G
Q
D
W
M
A
A
Y
Q
V
E
P
L
K
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001108317
541
61514
Y447
G
Q
D
W
Q
R
Y
Y
K
V
E
P
L
D
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8WSF3
660
75468
G545
F
G
S
W
R
A
T
G
D
A
A
C
A
P
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22492
555
64361
I441
G
A
D
W
R
D
E
I
R
G
T
A
P
S
N
Sea Urchin
Strong. purpuratus
XP_799340
543
61806
Y449
G
D
D
W
R
K
Y
Y
V
V
E
P
T
L
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001142218
433
49746
R347
K
V
E
P
L
A
F
R
G
T
P
A
Q
K
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
95.8
63.6
N.A.
73.3
71.9
N.A.
64.4
54.3
N.A.
59.7
N.A.
30.1
N.A.
40.8
49.6
Protein Similarity:
100
99.4
97.3
74
N.A.
85.2
83.6
N.A.
77.3
69.5
N.A.
72.1
N.A.
43.7
N.A.
57.9
65.6
P-Site Identity:
100
100
100
80
N.A.
80
80
N.A.
80
66.6
N.A.
86.6
N.A.
13.3
N.A.
26.6
73.3
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
86.6
N.A.
93.3
73.3
N.A.
100
N.A.
20
N.A.
33.3
73.3
Percent
Protein Identity:
N.A.
48.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
60.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
24
8
0
0
16
8
16
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
8
85
0
0
8
0
0
8
0
8
0
0
39
0
% D
% Glu:
0
0
8
0
0
0
8
0
0
0
70
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
77
% F
% Gly:
85
8
0
0
0
8
0
8
8
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
24
39
0
0
54
0
0
0
0
16
0
% K
% Leu:
0
0
0
0
8
0
0
0
0
0
0
0
70
8
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
16
0
0
0
0
0
0
0
24
8
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
8
77
8
8
0
% P
% Gln:
0
70
0
0
8
0
0
0
8
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
54
8
0
8
8
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
0
0
0
8
0
0
0
0
8
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
8
8
0
8
0
0
% T
% Val:
0
8
0
0
0
0
0
0
8
70
0
0
0
0
0
% V
% Trp:
0
0
0
93
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
70
77
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _