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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSB
All Species:
25.45
Human Site:
S175
Identified Species:
56
UniProt:
P07858
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07858
NP_001899.1
339
37822
S175
V
S
G
G
L
Y
E
S
H
V
G
C
R
P
Y
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543203
420
46164
S256
V
S
G
G
L
Y
D
S
H
V
G
C
R
P
Y
Cat
Felis silvestris
Mouse
Mus musculus
P10605
339
37261
S175
V
S
G
G
V
Y
N
S
H
V
G
C
L
P
Y
Rat
Rattus norvegicus
P00787
339
37451
S175
V
S
G
G
V
Y
N
S
H
I
G
C
L
P
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P43233
340
37569
S175
V
S
G
G
L
Y
D
S
H
V
G
C
R
A
Y
Frog
Xenopus laevis
NP_001080410
333
36451
S175
V
S
G
G
L
Y
D
S
H
V
G
C
R
P
Y
Zebra Danio
Brachydanio rerio
NP_998501
330
36310
C177
L
Y
N
S
H
I
G
C
R
P
Y
T
I
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572920
340
37406
S181
V
S
G
G
P
Y
G
S
N
Q
G
C
R
P
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43509
344
37373
Y177
G
L
V
T
G
G
S
Y
E
T
Q
F
G
C
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
T184
E
A
A
Y
T
Q
A
T
G
K
P
I
S
L
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
F182
E
A
A
Y
H
Q
A
F
G
K
G
I
S
L
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
68.5
N.A.
78.7
78.1
N.A.
N.A.
76.1
73.1
70.8
N.A.
56.7
N.A.
48.5
N.A.
Protein Similarity:
100
N.A.
N.A.
75.2
N.A.
87.9
88.5
N.A.
N.A.
86.4
82.3
83.4
N.A.
69.7
N.A.
61.3
N.A.
P-Site Identity:
100
N.A.
N.A.
93.3
N.A.
80
73.3
N.A.
N.A.
86.6
93.3
0
N.A.
73.3
N.A.
0
N.A.
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
86.6
86.6
N.A.
N.A.
93.3
100
6.6
N.A.
80
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
22.5
N.A.
22.3
N.A.
N.A.
Protein Similarity:
N.A.
38.3
N.A.
39.1
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
19
0
0
0
19
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
64
0
10
0
% C
% Asp:
0
0
0
0
0
0
28
0
0
0
0
0
0
0
0
% D
% Glu:
19
0
0
0
0
0
10
0
10
0
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
0
% F
% Gly:
10
0
64
64
10
10
19
0
19
0
73
0
10
0
0
% G
% His:
0
0
0
0
19
0
0
0
55
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
10
0
19
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
10
% K
% Leu:
10
10
0
0
37
0
0
0
0
0
0
0
19
19
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
19
0
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
0
0
0
0
10
10
0
0
55
10
% P
% Gln:
0
0
0
0
0
19
0
0
0
10
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
10
0
0
0
46
0
0
% R
% Ser:
0
64
0
10
0
0
10
64
0
0
0
0
19
0
19
% S
% Thr:
0
0
0
10
10
0
0
10
0
10
0
10
0
0
0
% T
% Val:
64
0
10
0
19
0
0
0
0
46
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
19
0
64
0
10
0
0
10
0
0
0
64
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _