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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSB
All Species:
17.27
Human Site:
S229
Identified Species:
38
UniProt:
P07858
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07858
NP_001899.1
339
37822
S229
D
K
H
Y
G
Y
N
S
Y
S
V
S
N
S
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543203
420
46164
S310
D
K
H
Y
G
C
S
S
Y
S
V
S
D
N
E
Cat
Felis silvestris
Mouse
Mus musculus
P10605
339
37261
S229
D
K
H
F
G
Y
T
S
Y
S
V
S
N
S
V
Rat
Rattus norvegicus
P00787
339
37451
S229
D
K
H
Y
G
Y
T
S
Y
S
V
S
D
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P43233
340
37569
T229
E
D
K
H
Y
G
I
T
S
Y
G
V
P
R
S
Frog
Xenopus laevis
NP_001080410
333
36451
T229
S
D
K
H
F
G
A
T
S
Y
G
V
P
S
S
Zebra Danio
Brachydanio rerio
NP_998501
330
36310
V231
F
G
K
T
S
Y
S
V
P
S
N
Q
N
S
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572920
340
37406
S235
D
K
H
F
G
S
K
S
Y
S
V
R
R
N
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43509
344
37373
K231
A
T
P
Y
L
Q
D
K
H
F
G
S
T
A
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
G238
Y
P
Y
Q
G
V
N
G
I
C
K
F
K
N
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
E236
Y
P
Y
T
G
K
D
E
T
C
K
F
S
A
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
68.5
N.A.
78.7
78.1
N.A.
N.A.
76.1
73.1
70.8
N.A.
56.7
N.A.
48.5
N.A.
Protein Similarity:
100
N.A.
N.A.
75.2
N.A.
87.9
88.5
N.A.
N.A.
86.4
82.3
83.4
N.A.
69.7
N.A.
61.3
N.A.
P-Site Identity:
100
N.A.
N.A.
73.3
N.A.
80
86.6
N.A.
N.A.
0
6.6
26.6
N.A.
53.3
N.A.
13.3
N.A.
P-Site Similarity:
100
N.A.
N.A.
93.3
N.A.
86.6
93.3
N.A.
N.A.
20
20
33.3
N.A.
66.6
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
22.5
N.A.
22.3
N.A.
N.A.
Protein Similarity:
N.A.
38.3
N.A.
39.1
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
10
0
0
0
0
0
0
19
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
19
0
0
0
0
0
% C
% Asp:
46
19
0
0
0
0
19
0
0
0
0
0
19
0
0
% D
% Glu:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
46
% E
% Phe:
10
0
0
19
10
0
0
0
0
10
0
19
0
0
0
% F
% Gly:
0
10
0
0
64
19
0
10
0
0
28
0
0
0
0
% G
% His:
0
0
46
19
0
0
0
0
10
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
10
0
10
0
0
0
0
0
10
% I
% Lys:
0
46
28
0
0
10
10
10
0
0
19
0
10
0
0
% K
% Leu:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
19
0
0
0
10
0
28
28
0
% N
% Pro:
0
19
10
0
0
0
0
0
10
0
0
0
19
0
0
% P
% Gln:
0
0
0
10
0
10
0
0
0
0
0
10
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
10
10
0
% R
% Ser:
10
0
0
0
10
10
19
46
19
55
0
46
10
46
19
% S
% Thr:
0
10
0
19
0
0
19
19
10
0
0
0
10
0
0
% T
% Val:
0
0
0
0
0
10
0
10
0
0
46
19
0
0
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
19
0
19
37
10
37
0
0
46
19
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _