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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSB
All Species:
18.79
Human Site:
T204
Identified Species:
41.33
UniProt:
P07858
Number Species:
10
Phosphosite Substitution
Charge Score:
0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07858
NP_001899.1
339
37822
T204
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543203
420
46164
T285
P
C
T
G
E
G
D
T
P
K
C
S
K
I
C
Cat
Felis silvestris
Mouse
Mus musculus
P10605
339
37261
T204
P
C
T
G
E
G
D
T
P
R
C
N
K
S
C
Rat
Rattus norvegicus
P00787
339
37451
T204
P
C
T
G
E
G
D
T
P
K
C
N
K
M
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P43233
340
37569
E204
P
C
T
G
E
G
G
E
T
P
R
C
S
R
H
Frog
Xenopus laevis
NP_001080410
333
36451
D204
S
C
K
G
E
E
G
D
T
P
K
C
M
K
T
Zebra Danio
Brachydanio rerio
NP_998501
330
36310
C206
E
G
G
D
T
P
N
C
D
M
K
C
E
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572920
340
37406
T210
P
C
A
H
G
G
R
T
P
K
C
S
H
V
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43509
344
37373
D206
K
W
P
A
C
P
E
D
T
E
P
T
P
K
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
S213
G
C
N
G
G
L
P
S
Q
A
F
E
Y
I
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
S211
G
C
N
G
G
L
P
S
Q
A
F
E
Y
I
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
68.5
N.A.
78.7
78.1
N.A.
N.A.
76.1
73.1
70.8
N.A.
56.7
N.A.
48.5
N.A.
Protein Similarity:
100
N.A.
N.A.
75.2
N.A.
87.9
88.5
N.A.
N.A.
86.4
82.3
83.4
N.A.
69.7
N.A.
61.3
N.A.
P-Site Identity:
100
N.A.
N.A.
100
N.A.
80
86.6
N.A.
N.A.
40
20
0
N.A.
60
N.A.
6.6
N.A.
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
93.3
100
N.A.
N.A.
40
20
13.3
N.A.
66.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
22.5
N.A.
22.3
N.A.
N.A.
Protein Similarity:
N.A.
38.3
N.A.
39.1
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
0
0
0
19
0
0
0
0
0
% A
% Cys:
0
82
0
0
10
0
0
10
0
0
46
28
0
0
55
% C
% Asp:
0
0
0
10
0
0
37
19
10
0
0
0
0
0
0
% D
% Glu:
10
0
0
0
55
10
10
10
0
10
0
19
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
19
0
0
0
0
% F
% Gly:
19
10
10
73
28
55
19
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
37
0
% I
% Lys:
10
0
10
0
0
0
0
0
0
37
19
0
37
19
19
% K
% Leu:
0
0
0
0
0
19
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
0
10
10
0
% M
% Asn:
0
0
19
0
0
0
10
0
0
0
0
19
0
0
0
% N
% Pro:
55
0
10
0
0
19
19
0
46
19
10
0
10
10
0
% P
% Gln:
0
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
0
0
10
10
0
0
10
0
% R
% Ser:
10
0
0
0
0
0
0
19
0
0
0
28
10
10
0
% S
% Thr:
0
0
46
0
10
0
0
46
28
0
0
10
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _