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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSB
All Species:
12.12
Human Site:
Y225
Identified Species:
26.67
UniProt:
P07858
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07858
NP_001899.1
339
37822
Y225
T
Y
K
Q
D
K
H
Y
G
Y
N
S
Y
S
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543203
420
46164
Y306
S
Y
K
E
D
K
H
Y
G
C
S
S
Y
S
V
Cat
Felis silvestris
Mouse
Mus musculus
P10605
339
37261
F225
S
Y
K
E
D
K
H
F
G
Y
T
S
Y
S
V
Rat
Rattus norvegicus
P00787
339
37451
Y225
S
Y
K
E
D
K
H
Y
G
Y
T
S
Y
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P43233
340
37569
H225
P
S
Y
K
E
D
K
H
Y
G
I
T
S
Y
G
Frog
Xenopus laevis
NP_001080410
333
36451
H225
P
A
Y
G
S
D
K
H
F
G
A
T
S
Y
G
Zebra Danio
Brachydanio rerio
NP_998501
330
36310
T227
Q
D
K
H
F
G
K
T
S
Y
S
V
P
S
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572920
340
37406
F231
D
Y
A
K
D
K
H
F
G
S
K
S
Y
S
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43509
344
37373
Y227
K
N
N
Y
A
T
P
Y
L
Q
D
K
H
F
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
Q234
T
E
E
S
Y
P
Y
Q
G
V
N
G
I
C
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
T232
T
E
K
A
Y
P
Y
T
G
K
D
E
T
C
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
68.5
N.A.
78.7
78.1
N.A.
N.A.
76.1
73.1
70.8
N.A.
56.7
N.A.
48.5
N.A.
Protein Similarity:
100
N.A.
N.A.
75.2
N.A.
87.9
88.5
N.A.
N.A.
86.4
82.3
83.4
N.A.
69.7
N.A.
61.3
N.A.
P-Site Identity:
100
N.A.
N.A.
73.3
N.A.
73.3
80
N.A.
N.A.
0
0
20
N.A.
60
N.A.
6.6
N.A.
P-Site Similarity:
100
N.A.
N.A.
93.3
N.A.
93.3
93.3
N.A.
N.A.
26.6
13.3
26.6
N.A.
73.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
22.5
N.A.
22.3
N.A.
N.A.
Protein Similarity:
N.A.
38.3
N.A.
39.1
N.A.
N.A.
P-Site Identity:
N.A.
20
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
10
10
0
0
0
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
19
0
% C
% Asp:
10
10
0
0
46
19
0
0
0
0
19
0
0
0
0
% D
% Glu:
0
19
10
28
10
0
0
0
0
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
10
0
0
19
10
0
0
0
0
10
0
% F
% Gly:
0
0
0
10
0
10
0
0
64
19
0
10
0
0
28
% G
% His:
0
0
0
10
0
0
46
19
0
0
0
0
10
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% I
% Lys:
10
0
55
19
0
46
28
0
0
10
10
10
0
0
19
% K
% Leu:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
10
0
0
0
0
0
0
0
19
0
0
0
10
% N
% Pro:
19
0
0
0
0
19
10
0
0
0
0
0
10
0
0
% P
% Gln:
10
0
0
10
0
0
0
10
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
28
10
0
10
10
0
0
0
10
10
19
46
19
55
0
% S
% Thr:
28
0
0
0
0
10
0
19
0
0
19
19
10
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
46
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
46
19
10
19
0
19
37
10
37
0
0
46
19
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _