KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RET
All Species:
8.48
Human Site:
S819
Identified Species:
16.97
UniProt:
P07949
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07949
NP_065681.1
1114
124319
S819
L
R
G
F
L
R
E
S
R
K
V
G
P
G
Y
Chimpanzee
Pan troglodytes
XP_001171246
813
90715
L538
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
Rhesus Macaque
Macaca mulatta
XP_001090823
731
81824
L456
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
Dog
Lupus familis
XP_543915
1108
124018
S813
L
R
G
F
L
R
E
S
R
K
A
G
P
G
Y
Cat
Felis silvestris
Mouse
Mus musculus
P35546
1115
123855
S820
L
R
G
F
L
R
D
S
R
K
I
G
P
A
Y
Rat
Rattus norvegicus
Q04589
822
91806
L547
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507715
665
75620
D390
N
R
N
S
S
Y
L
D
N
P
D
E
R
A
L
Chicken
Gallus gallus
P18461
823
92281
N548
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
Frog
Xenopus laevis
Q03364
813
91322
I538
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Zebra Danio
Brachydanio rerio
Q8JG38
817
91370
N542
K
M
I
G
R
H
K
N
I
I
N
L
L
G
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q09147
1052
117795
I776
M
K
M
I
G
K
H
I
N
I
I
N
L
L
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Q26614
972
110463
I697
E
L
A
M
M
K
M
I
G
K
N
P
N
I
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28.4
27.9
86.4
N.A.
83.4
28.9
N.A.
43
27.5
28.1
27.7
N.A.
23.6
N.A.
N.A.
24
Protein Similarity:
100
42.2
41.5
92
N.A.
90.2
43
N.A.
50.5
43.5
42.3
42
N.A.
37.7
N.A.
N.A.
41.2
P-Site Identity:
100
0
0
93.3
N.A.
80
0
N.A.
6.6
6.6
6.6
6.6
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
6.6
6.6
93.3
N.A.
93.3
6.6
N.A.
6.6
20
20
20
N.A.
26.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
0
0
0
34
0
9
17
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
25
0
9
0
% C
% Asp:
0
0
0
0
0
0
9
9
0
0
9
0
0
0
25
% D
% Glu:
9
0
0
0
0
0
17
0
0
0
0
9
0
0
0
% E
% Phe:
0
0
0
25
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
25
17
9
0
0
0
9
25
0
34
0
34
9
% G
% His:
0
25
0
9
0
17
9
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
17
9
25
25
9
25
17
25
17
0
0
9
9
% I
% Lys:
42
9
34
0
17
17
17
0
0
34
0
0
0
0
0
% K
% Leu:
25
9
0
0
25
0
9
25
25
9
9
17
25
9
9
% L
% Met:
9
17
9
9
9
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
9
25
0
9
25
17
25
0
25
9
9
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
9
0
9
25
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
25
0
% Q
% Arg:
0
34
0
0
9
25
0
0
25
0
0
0
9
0
0
% R
% Ser:
0
0
0
9
9
0
0
25
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
25
0
9
% T
% Val:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
25
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _