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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC1 All Species: 21.52
Human Site: S159 Identified Species: 36.41
UniProt: P07992 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.31
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07992 NP_001974.1 297 32562 S159 Y I H G R L Q S L G K N F A L
Chimpanzee Pan troglodytes XP_001164747 297 32515 S159 Y I H G R L Q S L G K N F A L
Rhesus Macaque Macaca mulatta XP_001105868 201 21761 N110 V S P R Q R G N P V L K F V R
Dog Lupus familis XP_855116 294 32368 S155 Y I H E R L Q S L G K S F A L
Cat Felis silvestris
Mouse Mus musculus P07903 298 32951 S159 Y I H E R L Q S L G K N F A L
Rat Rattus norvegicus NP_001099698 298 32624 S159 Y I H E R L Q S L G K N F A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517592 450 49542 G311 Y I H E R L Q G L G K T Y Q L
Chicken Gallus gallus
Frog Xenopus laevis NP_001080498 289 32423 S158 Y I H S R L R S L G Q S F A L
Zebra Danio Brachydanio rerio NP_001096608 342 37871 Q200 Y V H E R L K Q L G Q S F S L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623717 241 27330 L136 C I L A D L T L M L A W N P E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_791729 471 51103 E318 Y I S D R L T E L G H K F D L
Poplar Tree Populus trichocarpa XP_002328427 382 43165 E155 Y L Y Y R I R E L Q K N C K L
Maize Zea mays NP_001131279 397 43604 E168 Y L Y Y R I R E L Q K N F R L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9MA98 410 45730 E184 Y L Y F R I R E L Q K N F K L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 65.3 88.5 N.A. 86.2 83.5 N.A. 47.7 N.A. 51.8 52.9 N.A. N.A. 44.7 N.A. 37.7
Protein Similarity: 100 99.6 66.3 91.2 N.A. 91.6 89.9 N.A. 56.4 N.A. 67 68.4 N.A. N.A. 63.2 N.A. 48.4
P-Site Identity: 100 100 6.6 86.6 N.A. 93.3 93.3 N.A. 66.6 N.A. 73.3 53.3 N.A. N.A. 13.3 N.A. 53.3
P-Site Similarity: 100 100 20 93.3 N.A. 93.3 93.3 N.A. 73.3 N.A. 93.3 86.6 N.A. N.A. 20 N.A. 53.3
Percent
Protein Identity: 34.8 33 N.A. 33.4 N.A. N.A.
Protein Similarity: 48.9 47.6 N.A. 47.3 N.A. N.A.
P-Site Identity: 40 46.6 N.A. 46.6 N.A. N.A.
P-Site Similarity: 66.6 73.3 N.A. 73.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 0 0 8 0 0 43 0 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 0 8 8 0 0 0 0 0 0 0 0 8 0 % D
% Glu: 0 0 0 36 0 0 0 29 0 0 0 0 0 0 8 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 79 0 0 % F
% Gly: 0 0 0 15 0 0 8 8 0 65 0 0 0 0 0 % G
% His: 0 0 58 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 65 0 0 0 22 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 8 0 0 0 65 15 0 15 0 % K
% Leu: 0 22 8 0 0 72 0 8 86 8 8 0 0 0 86 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 0 50 8 0 0 % N
% Pro: 0 0 8 0 0 0 0 0 8 0 0 0 0 8 0 % P
% Gln: 0 0 0 0 8 0 43 8 0 22 15 0 0 8 0 % Q
% Arg: 0 0 0 8 86 8 29 0 0 0 0 0 0 8 8 % R
% Ser: 0 8 8 8 0 0 0 43 0 0 0 22 0 8 0 % S
% Thr: 0 0 0 0 0 0 15 0 0 0 0 8 0 0 0 % T
% Val: 8 8 0 0 0 0 0 0 0 8 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 86 0 22 15 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _