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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC1 All Species: 10.3
Human Site: S45 Identified Species: 17.44
UniProt: P07992 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07992 NP_001974.1 297 32562 S45 P L F R S T Q S L P T V D T S
Chimpanzee Pan troglodytes XP_001164747 297 32515 S45 P L F R S T Q S L P T V D T S
Rhesus Macaque Macaca mulatta XP_001105868 201 21761
Dog Lupus familis XP_855116 294 32368 S41 P L F K S T R S L P T V E T S
Cat Felis silvestris
Mouse Mus musculus P07903 298 32951 N45 P L F R S S R N P T I P A T S
Rat Rattus norvegicus NP_001099698 298 32624 N45 P L F K S S R N P T P T A A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517592 450 49542 P197 E P P G P V K P L F K A G A A
Chicken Gallus gallus
Frog Xenopus laevis NP_001080498 289 32423 E44 F Q A S E K V E T V P K A G S
Zebra Danio Brachydanio rerio NP_001096608 342 37871 N86 A P G Q S S A N I A V I E S V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623717 241 27330 A32 S I P G P S K A K D S L K F S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_791729 471 51103 E204 Y R L P Q A S E I A R R G K I
Poplar Tree Populus trichocarpa XP_002328427 382 43165 Q41 S S Q V K P T Q T Q E S S L F
Maize Zea mays NP_001131279 397 43604 A54 V A T S A A A A A S S S S S S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9MA98 410 45730 S70 V K S S D V Y S P P P P S S A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 65.3 88.5 N.A. 86.2 83.5 N.A. 47.7 N.A. 51.8 52.9 N.A. N.A. 44.7 N.A. 37.7
Protein Similarity: 100 99.6 66.3 91.2 N.A. 91.6 89.9 N.A. 56.4 N.A. 67 68.4 N.A. N.A. 63.2 N.A. 48.4
P-Site Identity: 100 100 0 80 N.A. 46.6 33.3 N.A. 6.6 N.A. 6.6 6.6 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 100 0 100 N.A. 66.6 60 N.A. 20 N.A. 6.6 53.3 N.A. N.A. 46.6 N.A. 6.6
Percent
Protein Identity: 34.8 33 N.A. 33.4 N.A. N.A.
Protein Similarity: 48.9 47.6 N.A. 47.3 N.A. N.A.
P-Site Identity: 0 6.6 N.A. 13.3 N.A. N.A.
P-Site Similarity: 0 33.3 N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 8 15 15 15 8 15 0 8 22 15 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 0 8 0 0 15 0 0 % D
% Glu: 8 0 0 0 8 0 0 15 0 0 8 0 15 0 0 % E
% Phe: 8 0 36 0 0 0 0 0 0 8 0 0 0 8 8 % F
% Gly: 0 0 8 15 0 0 0 0 0 0 0 0 15 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 15 0 8 8 0 0 8 % I
% Lys: 0 8 0 15 8 8 15 0 8 0 8 8 8 8 0 % K
% Leu: 0 36 8 0 0 0 0 0 29 0 0 8 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 22 0 0 0 0 0 0 0 % N
% Pro: 36 15 15 8 15 8 0 8 22 29 22 15 0 0 0 % P
% Gln: 0 8 8 8 8 0 15 8 0 8 0 0 0 0 0 % Q
% Arg: 0 8 0 22 0 0 22 0 0 0 8 8 0 0 0 % R
% Ser: 15 8 8 22 43 29 8 29 0 8 15 15 22 22 58 % S
% Thr: 0 0 8 0 0 22 8 0 15 15 22 8 0 29 0 % T
% Val: 15 0 0 8 0 15 8 0 0 8 8 22 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _