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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRM2
All Species:
31.21
Human Site:
Y459
Identified Species:
57.22
UniProt:
P08172
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08172
NP_000730.1
466
51715
Y459
K
H
L
L
M
C
H
Y
K
N
I
G
A
T
R
Chimpanzee
Pan troglodytes
Q9N2A7
440
48835
Rhesus Macaque
Macaca mulatta
P56489
460
51414
S451
K
I
P
K
R
P
G
S
V
H
R
T
P
S
R
Dog
Lupus familis
XP_532731
466
51597
Y459
K
H
L
L
M
C
H
Y
K
N
I
G
A
T
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERZ4
466
51496
Y459
K
H
L
L
M
C
H
Y
K
N
I
G
A
T
R
Rat
Rattus norvegicus
P10980
466
51520
Y459
K
H
L
L
M
C
H
Y
K
N
I
G
A
T
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513098
468
51540
Y461
K
H
L
L
L
C
H
Y
K
N
I
G
A
T
R
Chicken
Gallus gallus
P30372
466
51547
Y459
K
H
L
L
M
C
H
Y
K
N
I
G
A
T
R
Frog
Xenopus laevis
P30544
484
54107
Y477
K
H
L
L
M
C
Q
Y
K
S
I
G
T
A
R
Zebra Danio
Brachydanio rerio
NP_840086
495
54483
Y488
K
Q
L
L
L
C
Q
Y
K
N
I
R
S
T
R
Tiger Blowfish
Takifugu rubipres
O42385
423
46982
Fruit Fly
Dros. melanogaster
P16395
805
86605
W791
V
R
I
L
T
C
K
W
H
T
R
N
R
E
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U7D5
611
69544
F596
M
R
I
L
R
C
K
F
K
A
E
R
P
T
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
45.9
97.4
N.A.
96.1
96.3
N.A.
84.4
86.4
57.2
68.6
28.3
30.5
N.A.
32.9
N.A.
Protein Similarity:
100
94.4
62.2
98.7
N.A.
97.8
97.8
N.A.
90.8
90.7
68.5
77.5
48
41.8
N.A.
50.4
N.A.
P-Site Identity:
100
0
13.3
100
N.A.
100
100
N.A.
93.3
100
73.3
66.6
0
13.3
N.A.
26.6
N.A.
P-Site Similarity:
100
0
26.6
100
N.A.
100
100
N.A.
100
100
80
80
0
26.6
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
0
0
47
8
0
% A
% Cys:
0
0
0
0
0
77
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
54
0
0
8
% G
% His:
0
54
0
0
0
0
47
0
8
8
0
0
0
0
0
% H
% Ile:
0
8
16
0
0
0
0
0
0
0
62
0
0
0
0
% I
% Lys:
70
0
0
8
0
0
16
0
70
0
0
0
0
0
0
% K
% Leu:
0
0
62
77
16
0
0
0
0
0
0
0
0
0
0
% L
% Met:
8
0
0
0
47
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
54
0
8
0
0
0
% N
% Pro:
0
0
8
0
0
8
0
0
0
0
0
0
16
0
0
% P
% Gln:
0
8
0
0
0
0
16
0
0
0
0
0
0
0
0
% Q
% Arg:
0
16
0
0
16
0
0
0
0
0
16
16
8
0
70
% R
% Ser:
0
0
0
0
0
0
0
8
0
8
0
0
8
8
0
% S
% Thr:
0
0
0
0
8
0
0
0
0
8
0
8
8
62
0
% T
% Val:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
62
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _