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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRM4
All Species:
19.39
Human Site:
S247
Identified Species:
38.79
UniProt:
P08173
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08173
NP_000732.2
479
53049
S247
K
T
L
A
F
L
K
S
P
L
M
K
Q
S
V
Chimpanzee
Pan troglodytes
Q9N2A7
440
48835
P240
K
I
Q
N
G
K
A
P
R
D
P
V
T
E
N
Rhesus Macaque
Macaca mulatta
P56490
532
60122
R247
E
K
R
K
P
A
H
R
A
L
F
R
S
C
L
Dog
Lupus familis
XP_854065
478
52921
S246
K
T
L
A
F
L
K
S
P
L
M
K
Q
S
I
Cat
Felis silvestris
Mouse
Mus musculus
P32211
479
52955
S246
K
T
L
A
F
L
K
S
P
L
M
K
P
S
I
Rat
Rattus norvegicus
P08485
478
52892
S246
K
T
L
A
F
L
K
S
P
L
M
K
P
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513098
468
51540
G240
V
S
P
S
L
V
H
G
R
I
V
K
P
S
N
Chicken
Gallus gallus
P17200
490
54918
A257
K
S
L
S
F
F
K
A
P
P
V
K
Q
N
N
Frog
Xenopus laevis
P30544
484
54107
S247
K
P
I
S
S
M
K
S
L
L
I
K
Q
T
K
Zebra Danio
Brachydanio rerio
XP_001922442
513
56067
S273
K
S
S
G
L
L
K
S
H
I
L
K
Q
N
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16395
805
86605
N322
R
S
N
S
S
D
E
N
T
V
V
N
H
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U7D5
611
69544
R304
F
S
R
R
S
M
K
R
D
V
S
S
T
S
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.6
43.7
98.1
N.A.
96
95.4
N.A.
58.8
73
70.6
68
N.A.
29.9
N.A.
32
N.A.
Protein Similarity:
100
65.1
59
99.3
N.A.
97.9
97
N.A.
70.3
82.6
80.1
78.9
N.A.
42.7
N.A.
49.4
N.A.
P-Site Identity:
100
6.6
6.6
93.3
N.A.
86.6
86.6
N.A.
13.3
46.6
40
40
N.A.
0
N.A.
13.3
N.A.
P-Site Similarity:
100
6.6
26.6
100
N.A.
93.3
93.3
N.A.
46.6
80
73.3
66.6
N.A.
53.3
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
34
0
9
9
9
9
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
9
0
0
9
9
0
0
0
0
0
% D
% Glu:
9
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% E
% Phe:
9
0
0
0
42
9
0
0
0
0
9
0
0
0
0
% F
% Gly:
0
0
0
9
9
0
0
9
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
17
0
9
0
0
0
9
0
0
% H
% Ile:
0
9
9
0
0
0
0
0
0
17
9
0
0
0
34
% I
% Lys:
67
9
0
9
0
9
67
0
0
0
0
67
0
0
9
% K
% Leu:
0
0
42
0
17
42
0
0
9
50
9
0
0
0
9
% L
% Met:
0
0
0
0
0
17
0
0
0
0
34
0
0
0
0
% M
% Asn:
0
0
9
9
0
0
0
9
0
0
0
9
0
17
34
% N
% Pro:
0
9
9
0
9
0
0
9
42
9
9
0
25
0
0
% P
% Gln:
0
0
9
0
0
0
0
0
0
0
0
0
42
0
0
% Q
% Arg:
9
0
17
9
0
0
0
17
17
0
0
9
0
0
0
% R
% Ser:
0
42
9
34
25
0
0
50
0
0
9
9
9
50
9
% S
% Thr:
0
34
0
0
0
0
0
0
9
0
0
0
17
9
0
% T
% Val:
9
0
0
0
0
9
0
0
0
17
25
9
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _