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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCB1 All Species: 12.73
Human Site: S644 Identified Species: 23.33
UniProt: P08183 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.42
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08183 NP_000918.2 1280 141479 S644 L E N A A D E S K S E I D A L
Chimpanzee Pan troglodytes XP_519183 1280 141455 S644 L E N A A D E S K S E I D A L
Rhesus Macaque Macaca mulatta NP_001028059 1283 141504 S647 L E N A A D E S K S E I D T L
Dog Lupus familis XP_539461 1269 140189 E637 E S M A Y S I E K K Y Q L S S
Cat Felis silvestris
Mouse Mus musculus P21447 1276 140628 S640 L G N E A C K S K D E I D N L
Rat Rattus norvegicus P43245 1277 141369 E642 E P G N N A Y E S Q S D T G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508941 1368 147746 E733 G N Q W E P E E S E E G D G G
Chicken Gallus gallus XP_418636 1307 144961 G672 E D Q L Q E E G N A S S V S E
Frog Xenopus laevis NP_001081394 1287 141487 H654 T E E D L E T H I Y E K K I P
Zebra Danio Brachydanio rerio XP_001922717 1340 147081 E707 G E D S S D P E I L E G G V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q00748 1302 143766 E657 V E K E D S I E D T K Q K S L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34712 1321 145045 S668 S A A E G K F S R E N S V A R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O80725 1286 139009 Q635 D E N A A E E Q K M S S I E S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96 55.7 N.A. 87.1 80.6 N.A. 62.1 69.6 67.6 56 N.A. 41.1 N.A. 44.5 N.A.
Protein Similarity: 100 99.8 97.7 75.4 N.A. 93.3 90.1 N.A. 76.6 83.6 81.8 73.5 N.A. 60.4 N.A. 62.6 N.A.
P-Site Identity: 100 100 93.3 13.3 N.A. 60 0 N.A. 20 6.6 13.3 20 N.A. 13.3 N.A. 13.3 N.A.
P-Site Similarity: 100 100 93.3 20 N.A. 66.6 0 N.A. 20 33.3 20 40 N.A. 40 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 41.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 62.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 40 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 39 39 8 0 0 0 8 0 0 0 24 8 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 8 8 8 31 0 0 8 8 0 8 39 0 0 % D
% Glu: 24 54 8 24 8 24 47 39 0 16 54 0 0 8 16 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 16 8 8 0 8 0 0 8 0 0 0 16 8 16 8 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 16 0 16 0 0 31 8 8 0 % I
% Lys: 0 0 8 0 0 8 8 0 47 8 8 8 16 0 0 % K
% Leu: 31 0 0 8 8 0 0 0 0 8 0 0 8 0 39 % L
% Met: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 8 39 8 8 0 0 0 8 0 8 0 0 8 0 % N
% Pro: 0 8 0 0 0 8 8 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 16 0 8 0 0 8 0 8 0 16 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % R
% Ser: 8 8 0 8 8 16 0 39 16 24 24 24 0 24 16 % S
% Thr: 8 0 0 0 0 0 8 0 0 8 0 0 8 8 0 % T
% Val: 8 0 0 0 0 0 0 0 0 0 0 0 16 8 0 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 8 0 0 8 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _