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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB1
All Species:
10.91
Human Site:
S646
Identified Species:
20
UniProt:
P08183
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08183
NP_000918.2
1280
141479
S646
N
A
A
D
E
S
K
S
E
I
D
A
L
E
M
Chimpanzee
Pan troglodytes
XP_519183
1280
141455
S646
N
A
A
D
E
S
K
S
E
I
D
A
L
E
M
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
S649
N
A
A
D
E
S
K
S
E
I
D
T
L
E
M
Dog
Lupus familis
XP_539461
1269
140189
K639
M
A
Y
S
I
E
K
K
Y
Q
L
S
S
S
G
Cat
Felis silvestris
Mouse
Mus musculus
P21447
1276
140628
D642
N
E
A
C
K
S
K
D
E
I
D
N
L
D
M
Rat
Rattus norvegicus
P43245
1277
141369
Q644
G
N
N
A
Y
E
S
Q
S
D
T
G
A
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
E735
Q
W
E
P
E
E
S
E
E
G
D
G
G
E
M
Chicken
Gallus gallus
XP_418636
1307
144961
A674
Q
L
Q
E
E
G
N
A
S
S
V
S
E
E
A
Frog
Xenopus laevis
NP_001081394
1287
141487
Y656
E
D
L
E
T
H
I
Y
E
K
K
I
P
V
T
Zebra Danio
Brachydanio rerio
XP_001922717
1340
147081
L709
D
S
S
D
P
E
I
L
E
G
G
V
E
M
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
T659
K
E
D
S
I
E
D
T
K
Q
K
S
L
A
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
E670
A
E
G
K
F
S
R
E
N
S
V
A
R
Q
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O80725
1286
139009
M637
N
A
A
E
E
Q
K
M
S
S
I
E
S
F
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96
55.7
N.A.
87.1
80.6
N.A.
62.1
69.6
67.6
56
N.A.
41.1
N.A.
44.5
N.A.
Protein Similarity:
100
99.8
97.7
75.4
N.A.
93.3
90.1
N.A.
76.6
83.6
81.8
73.5
N.A.
60.4
N.A.
62.6
N.A.
P-Site Identity:
100
100
93.3
13.3
N.A.
60
0
N.A.
33.3
13.3
6.6
13.3
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
100
93.3
20
N.A.
73.3
0
N.A.
33.3
33.3
13.3
33.3
N.A.
33.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
39
39
8
0
0
0
8
0
0
0
24
8
8
8
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
8
31
0
0
8
8
0
8
39
0
0
8
0
% D
% Glu:
8
24
8
24
47
39
0
16
54
0
0
8
16
39
8
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
8
0
8
0
0
8
0
0
0
16
8
16
8
0
8
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
16
0
16
0
0
31
8
8
0
0
0
% I
% Lys:
8
0
0
8
8
0
47
8
8
8
16
0
0
0
16
% K
% Leu:
0
8
8
0
0
0
0
8
0
0
8
0
39
0
8
% L
% Met:
8
0
0
0
0
0
0
8
0
0
0
0
0
8
39
% M
% Asn:
39
8
8
0
0
0
8
0
8
0
0
8
0
0
0
% N
% Pro:
0
0
0
8
8
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
16
0
8
0
0
8
0
8
0
16
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% R
% Ser:
0
8
8
16
0
39
16
24
24
24
0
24
16
16
0
% S
% Thr:
0
0
0
0
8
0
0
8
0
0
8
8
0
0
16
% T
% Val:
0
0
0
0
0
0
0
0
0
0
16
8
0
8
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
0
0
8
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _