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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCB1 All Species: 15.76
Human Site: T1023 Identified Species: 28.89
UniProt: P08183 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.42
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08183 NP_000918.2 1280 141479 T1023 P L I D S Y S T E G L M P N T
Chimpanzee Pan troglodytes XP_519183 1280 141455 T1023 P L I D S Y S T E G L T P N T
Rhesus Macaque Macaca mulatta NP_001028059 1283 141504 T1026 P L I D S Y S T E G L K P N T
Dog Lupus familis XP_539461 1269 140189 Q1015 P T I D S Y S Q E G K K T D T
Cat Felis silvestris
Mouse Mus musculus P21447 1276 140628 T1019 P E I D S Y S T Q G L K P N M
Rat Rattus norvegicus P43245 1277 141369 T1023 P E I D S Y S T E G L K P N W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508941 1368 147746 D1111 P L V D S C S D R G L K P V S
Chicken Gallus gallus XP_418636 1307 144961 E1050 P L I D S Y S E E G E K P K M
Frog Xenopus laevis NP_001081394 1287 141487 D1032 P Q I D S Y S D Q G E K P K N
Zebra Danio Brachydanio rerio XP_001922717 1340 147081 E1085 P E I D I Y D E S G E R P S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q00748 1302 143766 G1043 P K I Q S P M G T I K N T L A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34712 1321 145045 L1064 K I S K I D S L S L A G E K K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O80725 1286 139009 E1030 S K I D P S V E S G R V L D N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 96 55.7 N.A. 87.1 80.6 N.A. 62.1 69.6 67.6 56 N.A. 41.1 N.A. 44.5 N.A.
Protein Similarity: 100 99.8 97.7 75.4 N.A. 93.3 90.1 N.A. 76.6 83.6 81.8 73.5 N.A. 60.4 N.A. 62.6 N.A.
P-Site Identity: 100 93.3 93.3 60 N.A. 73.3 80 N.A. 53.3 66.6 53.3 46.6 N.A. 20 N.A. 6.6 N.A.
P-Site Similarity: 100 93.3 93.3 66.6 N.A. 80 80 N.A. 66.6 66.6 60 53.3 N.A. 20 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 41.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 62.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 85 0 8 8 16 0 0 0 0 0 16 0 % D
% Glu: 0 24 0 0 0 0 0 24 47 0 24 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 85 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 85 0 16 0 0 0 0 8 0 0 0 0 0 % I
% Lys: 8 16 0 8 0 0 0 0 0 0 16 54 0 24 8 % K
% Leu: 0 39 0 0 0 0 0 8 0 8 47 0 8 8 0 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 8 0 0 16 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 8 0 39 16 % N
% Pro: 85 0 0 0 8 8 0 0 0 0 0 0 70 0 0 % P
% Gln: 0 8 0 8 0 0 0 8 16 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 8 0 8 8 0 0 0 % R
% Ser: 8 0 8 0 77 8 77 0 24 0 0 0 0 8 8 % S
% Thr: 0 8 0 0 0 0 0 39 8 0 0 8 16 0 39 % T
% Val: 0 0 8 0 0 0 8 0 0 0 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 70 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _