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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB1
All Species:
47.58
Human Site:
Y1133
Identified Species:
87.22
UniProt:
P08183
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08183
NP_000918.2
1280
141479
Y1133
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
Chimpanzee
Pan troglodytes
XP_519183
1280
141455
Y1133
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
Y1136
S
I
S
E
N
I
A
Y
G
D
N
S
R
V
V
Dog
Lupus familis
XP_539461
1269
140189
Y1125
S
I
A
D
N
I
A
Y
G
D
N
S
R
V
V
Cat
Felis silvestris
Mouse
Mus musculus
P21447
1276
140628
Y1129
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
Rat
Rattus norvegicus
P43245
1277
141369
Y1132
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
Y1221
S
I
A
E
N
I
A
Y
G
D
L
G
R
A
V
Chicken
Gallus gallus
XP_418636
1307
144961
Y1160
T
I
A
E
N
I
A
Y
G
D
N
S
R
E
V
Frog
Xenopus laevis
NP_001081394
1287
141487
Y1142
S
I
G
D
N
I
A
Y
G
D
N
N
R
K
V
Zebra Danio
Brachydanio rerio
XP_001922717
1340
147081
Y1195
T
I
S
E
N
I
Q
Y
G
D
N
S
Q
T
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
Y1158
S
I
A
E
N
I
A
Y
G
D
N
R
R
S
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
Y1175
S
I
A
E
N
I
I
Y
G
L
D
P
S
S
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O80725
1286
139009
Y1140
T
I
R
A
N
I
A
Y
G
K
G
G
D
A
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96
55.7
N.A.
87.1
80.6
N.A.
62.1
69.6
67.6
56
N.A.
41.1
N.A.
44.5
N.A.
Protein Similarity:
100
99.8
97.7
75.4
N.A.
93.3
90.1
N.A.
76.6
83.6
81.8
73.5
N.A.
60.4
N.A.
62.6
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
100
100
N.A.
80
86.6
73.3
66.6
N.A.
86.6
N.A.
60
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
93.3
86.6
86.6
N.A.
86.6
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
70
8
0
0
85
0
0
0
0
0
0
16
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
0
0
0
0
0
85
8
0
8
0
0
% D
% Glu:
0
0
0
77
0
0
0
0
0
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
100
0
8
16
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
100
0
0
0
100
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
100
0
0
0
0
0
77
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
8
77
0
0
% R
% Ser:
77
0
16
0
0
0
0
0
0
0
0
62
8
16
8
% S
% Thr:
24
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
47
93
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _