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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKM
All Species:
21.21
Human Site:
T486
Identified Species:
38.89
UniProt:
P08237
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08237
NP_000280.1
780
85183
T486
E
Q
I
S
A
N
I
T
K
F
N
I
Q
G
L
Chimpanzee
Pan troglodytes
XP_001150233
780
84936
R485
E
S
I
V
E
N
I
R
I
Y
G
I
H
A
L
Rhesus Macaque
Macaca mulatta
XP_001096244
851
93251
T557
E
Q
I
S
A
N
I
T
K
F
N
I
Q
G
L
Dog
Lupus familis
XP_544922
751
82459
R456
E
K
I
V
D
N
I
R
T
Y
N
I
H
A
L
Cat
Felis silvestris
Mouse
Mus musculus
P47857
780
85250
T486
E
Q
I
S
A
N
I
T
K
F
N
I
Q
G
L
Rat
Rattus norvegicus
P47858
780
85541
T486
E
Q
I
S
A
N
I
T
K
Y
N
I
Q
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511162
864
94802
R567
E
Q
I
A
E
Q
M
R
T
H
N
I
N
A
L
Chicken
Gallus gallus
NP_989554
769
83907
S473
E
E
I
S
A
T
I
S
T
F
G
I
H
G
L
Frog
Xenopus laevis
NP_001086921
808
88294
S514
E
E
I
S
N
N
I
S
N
Y
N
I
H
G
L
Zebra Danio
Brachydanio rerio
NP_001004575
784
85614
A487
E
E
I
S
L
N
I
A
K
Y
N
I
H
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52034
788
86630
K495
K
E
I
A
A
R
L
K
E
F
K
I
Q
G
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27483
756
83282
S489
L
I
A
E
G
L
N
S
N
N
V
D
G
L
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P16862
959
104599
F673
L
G
M
I
A
Y
Y
F
Q
K
Y
E
F
D
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.5
90.4
67.6
N.A.
97.8
96.6
N.A.
65.2
81.2
81.4
77.8
N.A.
58.7
N.A.
39.6
N.A.
Protein Similarity:
100
82.8
91.1
81.7
N.A.
99
98.2
N.A.
76.2
90.1
90.3
88.7
N.A.
75.7
N.A.
57.6
N.A.
P-Site Identity:
100
40
100
46.6
N.A.
100
93.3
N.A.
40
60
60
60
N.A.
46.6
N.A.
0
N.A.
P-Site Similarity:
100
46.6
100
60
N.A.
100
100
N.A.
53.3
73.3
80
73.3
N.A.
80
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
34.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
16
54
0
0
8
0
0
0
0
0
31
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
8
0
8
0
% D
% Glu:
77
31
0
8
16
0
0
0
8
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
39
0
0
8
0
0
% F
% Gly:
0
8
0
0
8
0
0
0
0
0
16
0
8
54
8
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
39
0
0
% H
% Ile:
0
8
85
8
0
0
70
0
8
0
0
85
0
0
0
% I
% Lys:
8
8
0
0
0
0
0
8
39
8
8
0
0
0
0
% K
% Leu:
16
0
0
0
8
8
8
0
0
0
0
0
0
8
85
% L
% Met:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
62
8
0
16
8
62
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
39
0
0
0
8
0
0
8
0
0
0
39
0
0
% Q
% Arg:
0
0
0
0
0
8
0
24
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
54
0
0
0
24
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
8
0
31
24
0
0
0
0
0
0
% T
% Val:
0
0
0
16
0
0
0
0
0
0
8
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
8
0
0
39
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _