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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB1
All Species:
46.36
Human Site:
Y485
Identified Species:
78.46
UniProt:
P08238
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08238
NP_031381.2
724
83264
Y485
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
Y494
E
N
Q
K
H
I
Y
Y
I
T
G
E
T
K
D
Rhesus Macaque
Macaca mulatta
XP_001098520
724
83571
Y485
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
Y485
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Rat
Rattus norvegicus
P34058
724
83263
Y485
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
Y577
E
T
Q
K
C
I
Y
Y
I
T
G
E
S
K
E
Chicken
Gallus gallus
Q04619
725
83409
Y486
E
S
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Frog
Xenopus laevis
NP_001086624
722
82939
Y483
E
N
Q
K
S
I
Y
Y
I
T
G
E
S
K
D
Zebra Danio
Brachydanio rerio
O57521
725
83339
Y484
E
N
Q
K
S
I
Y
Y
I
T
G
E
S
K
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
F478
D
N
Q
K
H
V
Y
F
I
T
G
E
S
K
D
Honey Bee
Apis mellifera
XP_395168
718
82735
F481
E
N
Q
K
H
I
Y
F
I
T
G
E
S
K
D
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
Y463
E
N
Q
T
Q
I
Y
Y
I
T
G
E
S
K
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P27323
700
80617
Y465
E
G
Q
K
D
I
F
Y
I
T
G
E
S
K
K
Baker's Yeast
Sacchar. cerevisiae
P02829
709
81388
Y473
E
H
Q
K
N
I
Y
Y
I
T
G
E
S
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86
95.1
N.A.
N.A.
99.1
99.5
N.A.
86.8
94.7
92.4
91.4
N.A.
78.4
81.3
75.4
N.A.
Protein Similarity:
100
93.4
96.1
N.A.
N.A.
99.5
99.8
N.A.
87.5
97.7
96.6
97
N.A.
88.5
89.9
86.8
N.A.
P-Site Identity:
100
73.3
100
N.A.
N.A.
100
100
N.A.
93.3
93.3
86.6
86.6
N.A.
60
73.3
73.3
N.A.
P-Site Similarity:
100
86.6
100
N.A.
N.A.
100
100
N.A.
93.3
100
93.3
93.3
N.A.
86.6
86.6
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
69.6
61.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
83.8
78.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
73.3
73.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
43
% D
% Glu:
93
0
0
0
0
0
0
0
0
0
0
100
0
0
43
% E
% Phe:
0
0
0
0
0
0
8
15
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
100
0
0
0
0
% G
% His:
0
8
0
0
22
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
93
0
0
100
0
0
0
0
0
0
% I
% Lys:
0
0
0
93
0
0
0
0
0
0
0
0
0
93
15
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
43
0
0
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
100
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
50
0
0
0
0
0
0
0
93
0
0
% S
% Thr:
0
36
0
8
0
0
0
0
0
100
0
0
8
0
0
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
93
86
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _