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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SRPR All Species: 20
Human Site: S228 Identified Species: 33.85
UniProt: P08240 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08240 NP_003130.2 638 69811 S228 H G R G M E K S N K S T K S D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001112588 638 69763 S228 H G R G M E K S N K S T K S D
Dog Lupus familis XP_546411 612 66844 K214 K S D A P K E K G K K A P R V
Cat Felis silvestris
Mouse Mus musculus Q9DBG7 636 69604 S227 H G K G L D K S S K S T K S D
Rat Rattus norvegicus NP_001029322 636 69638 S227 H G K G L D K S S K S T K S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034366 644 71178 S229 H M K A G E K S S K S P K P D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_697518 650 71144 P226 K Q L G G G K P E K P S K S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9U5L1 614 67777 A215 K S S K P E K A G K K P R V W
Honey Bee Apis mellifera XP_395013 605 68213 E218 G K K P R V W E L G G T I K D
Nematode Worm Caenorhab. elegans NP_741303 625 69292 K223 K M S G N T K K K G P E E P T
Sea Urchin Strong. purpuratus XP_001188635 584 65767 A223 P T K K T K Q A T T W G M G G
Poplar Tree Populus trichocarpa XP_002309350 624 68615 S238 T S V V S K G S N V D P K K K
Maize Zea mays NP_001130574 625 68471 T243 N G A T D N G T K K L T K P D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32916 621 69260 L217 W G R D G G M L D E M N H E D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.5 92.9 N.A. 97.1 97.6 N.A. N.A. 78.7 N.A. 67.3 N.A. 51.4 58.1 49 52.8
Protein Similarity: 100 N.A. 99.6 93.7 N.A. 98.2 98.7 N.A. N.A. 87.4 N.A. 78.7 N.A. 69.7 71.6 66.1 63.9
P-Site Identity: 100 N.A. 100 6.6 N.A. 73.3 73.3 N.A. N.A. 53.3 N.A. 33.3 N.A. 20 13.3 13.3 0
P-Site Similarity: 100 N.A. 100 20 N.A. 100 100 N.A. N.A. 66.6 N.A. 40 N.A. 33.3 20 20 26.6
Percent
Protein Identity: 43.2 43.7 N.A. N.A. 31.6 N.A.
Protein Similarity: 59.5 61.1 N.A. N.A. 51.7 N.A.
P-Site Identity: 20 33.3 N.A. N.A. 20 N.A.
P-Site Similarity: 26.6 46.6 N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 15 0 0 0 15 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 8 8 15 0 0 8 0 8 0 0 0 58 % D
% Glu: 0 0 0 0 0 29 8 8 8 8 0 8 8 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 43 0 43 22 15 15 0 15 15 8 8 0 8 8 % G
% His: 36 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % I
% Lys: 29 8 36 15 0 22 58 15 15 65 15 0 58 15 8 % K
% Leu: 0 0 8 0 15 0 0 8 8 0 8 0 0 0 0 % L
% Met: 0 15 0 0 15 0 8 0 0 0 8 0 8 0 0 % M
% Asn: 8 0 0 0 8 8 0 0 22 0 0 8 0 0 0 % N
% Pro: 8 0 0 8 15 0 0 8 0 0 15 22 8 22 8 % P
% Gln: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 22 0 8 0 0 0 0 0 0 0 8 8 0 % R
% Ser: 0 22 15 0 8 0 0 43 22 0 36 8 0 36 0 % S
% Thr: 8 8 0 8 8 8 0 8 8 8 0 43 0 0 8 % T
% Val: 0 0 8 8 0 8 0 0 0 8 0 0 0 8 8 % V
% Trp: 8 0 0 0 0 0 8 0 0 0 8 0 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _