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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP2
All Species:
21.82
Human Site:
S448
Identified Species:
48
UniProt:
P08253
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08253
NP_001121363.1
660
73882
S448
I
Q
E
L
Y
G
A
S
P
D
I
D
L
G
T
Chimpanzee
Pan troglodytes
XP_001167520
660
73986
S448
I
Q
E
L
Y
G
A
S
P
D
I
D
L
G
T
Rhesus Macaque
Macaca mulatta
XP_001087939
660
73880
S448
I
Q
E
L
Y
G
A
S
P
D
I
D
L
G
T
Dog
Lupus familis
XP_535300
612
68986
F440
I
R
G
E
I
F
F
F
K
D
R
F
I
W
R
Cat
Felis silvestris
Mouse
Mus musculus
P33434
662
74084
S448
I
Q
E
L
Y
G
P
S
P
D
A
D
T
D
T
Rat
Rattus norvegicus
P33436
662
74131
S448
I
Q
E
L
Y
G
P
S
P
D
A
D
T
D
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508394
704
78508
S494
I
Q
E
L
Y
G
G
S
T
D
F
G
P
G
P
Chicken
Gallus gallus
Q90611
663
74923
S445
I
Q
E
L
Y
E
V
S
P
D
V
E
P
G
P
Frog
Xenopus laevis
O13065
467
52794
F298
T
M
R
G
E
L
I
F
F
V
K
R
F
L
W
Zebra Danio
Brachydanio rerio
NP_932333
657
74257
P448
I
Q
E
L
Y
G
E
P
T
D
K
P
L
A
T
Tiger Blowfish
Takifugu rubipres
NP_001032958
658
74198
V448
I
Q
E
L
Y
G
G
V
L
T
D
K
P
F
P
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.1
99.6
89.8
N.A.
95.6
95.1
N.A.
81.5
82.1
31.6
71.8
71.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.1
99.8
91.6
N.A.
97.4
97.1
N.A.
88.6
90.3
42.8
83.3
81.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
73.3
73.3
N.A.
60
60
0
60
40
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
73.3
73.3
N.A.
60
73.3
0
60
40
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
28
0
0
0
19
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
82
10
46
0
19
0
% D
% Glu:
0
0
82
10
10
10
10
0
0
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
10
10
19
10
0
10
10
10
10
0
% F
% Gly:
0
0
10
10
0
73
19
0
0
0
0
10
0
46
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
91
0
0
0
10
0
10
0
0
0
28
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
19
10
0
0
0
% K
% Leu:
0
0
0
82
0
10
0
0
10
0
0
0
37
10
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
19
10
55
0
0
10
28
0
28
% P
% Gln:
0
82
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
10
0
0
0
0
0
0
0
10
10
0
0
10
% R
% Ser:
0
0
0
0
0
0
0
64
0
0
0
0
0
0
0
% S
% Thr:
10
0
0
0
0
0
0
0
19
10
0
0
19
0
55
% T
% Val:
0
0
0
0
0
0
10
10
0
10
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% W
% Tyr:
0
0
0
0
82
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _