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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMBS
All Species:
19.39
Human Site:
S69
Identified Species:
42.67
UniProt:
P08397
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08397
NP_000181.2
361
39330
S69
K
I
L
D
T
A
L
S
K
I
G
E
K
S
L
Chimpanzee
Pan troglodytes
XP_001149046
276
30700
S45
V
V
T
T
L
K
A
S
Y
P
G
L
Q
F
E
Rhesus Macaque
Macaca mulatta
XP_001101850
361
39314
S69
K
I
L
D
T
A
L
S
K
I
G
E
K
S
L
Dog
Lupus familis
XP_546491
361
39305
S69
K
I
L
D
T
A
L
S
K
I
G
E
K
S
L
Cat
Felis silvestris
Mouse
Mus musculus
P22907
361
39284
S69
K
I
V
D
T
A
L
S
K
I
G
E
K
S
L
Rat
Rattus norvegicus
P19356
361
39343
S69
K
I
L
D
T
A
L
S
K
I
G
E
K
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417846
358
38973
G69
D
T
A
L
S
K
I
G
E
K
S
L
F
T
K
Frog
Xenopus laevis
NP_001089699
351
38279
L71
K
S
L
F
T
K
E
L
E
N
A
L
E
K
N
Zebra Danio
Brachydanio rerio
NP_001019559
360
39395
G69
D
T
A
L
S
K
I
G
E
K
S
L
F
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624261
357
39498
L70
K
S
L
F
T
E
E
L
E
L
A
L
E
S
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781025
324
36125
K70
L
F
T
K
E
L
E
K
A
L
A
L
D
E
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.2
99.1
94.1
N.A.
89.4
90.8
N.A.
N.A.
74.2
73.1
70.9
N.A.
N.A.
52.3
N.A.
44.8
Protein Similarity:
100
74.7
99.4
96.6
N.A.
94.1
93.9
N.A.
N.A.
84.7
82.2
80.8
N.A.
N.A.
67.3
N.A.
63.9
P-Site Identity:
100
13.3
100
100
N.A.
93.3
100
N.A.
N.A.
0
20
0
N.A.
N.A.
26.6
N.A.
0
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
N.A.
26.6
33.3
26.6
N.A.
N.A.
46.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
0
0
46
10
0
10
0
28
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
19
0
0
46
0
0
0
0
0
0
0
0
10
0
0
% D
% Glu:
0
0
0
0
10
10
28
0
37
0
0
46
19
10
10
% E
% Phe:
0
10
0
19
0
0
0
0
0
0
0
0
19
10
0
% F
% Gly:
0
0
0
0
0
0
0
19
0
0
55
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
46
0
0
0
0
19
0
0
46
0
0
0
0
0
% I
% Lys:
64
0
0
10
0
37
0
10
46
19
0
0
46
10
19
% K
% Leu:
10
0
55
19
10
10
46
19
0
19
0
55
0
0
46
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
19
0
0
19
0
0
55
0
0
19
0
0
55
0
% S
% Thr:
0
19
19
10
64
0
0
0
0
0
0
0
0
19
0
% T
% Val:
10
10
10
0
0
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _