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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMBS
All Species:
22.12
Human Site:
S75
Identified Species:
48.67
UniProt:
P08397
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08397
NP_000181.2
361
39330
S75
L
S
K
I
G
E
K
S
L
F
T
K
E
L
E
Chimpanzee
Pan troglodytes
XP_001149046
276
30700
F51
A
S
Y
P
G
L
Q
F
E
I
I
A
M
S
T
Rhesus Macaque
Macaca mulatta
XP_001101850
361
39314
S75
L
S
K
I
G
E
K
S
L
F
T
K
E
L
E
Dog
Lupus familis
XP_546491
361
39305
S75
L
S
K
I
G
E
K
S
L
F
T
K
E
L
E
Cat
Felis silvestris
Mouse
Mus musculus
P22907
361
39284
S75
L
S
K
I
G
E
K
S
L
F
T
K
E
L
E
Rat
Rattus norvegicus
P19356
361
39343
S75
L
S
K
I
G
E
K
S
L
F
T
K
E
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417846
358
38973
T75
I
G
E
K
S
L
F
T
K
E
L
E
N
A
L
Frog
Xenopus laevis
NP_001089699
351
38279
K77
E
L
E
N
A
L
E
K
N
E
V
D
L
V
V
Zebra Danio
Brachydanio rerio
NP_001019559
360
39395
T75
I
G
E
K
S
L
F
T
K
E
L
E
N
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624261
357
39498
S76
E
L
E
L
A
L
E
S
G
R
V
D
F
V
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781025
324
36125
E76
E
K
A
L
A
L
D
E
V
D
M
L
V
H
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.2
99.1
94.1
N.A.
89.4
90.8
N.A.
N.A.
74.2
73.1
70.9
N.A.
N.A.
52.3
N.A.
44.8
Protein Similarity:
100
74.7
99.4
96.6
N.A.
94.1
93.9
N.A.
N.A.
84.7
82.2
80.8
N.A.
N.A.
67.3
N.A.
63.9
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
0
0
0
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
N.A.
26.6
20
26.6
N.A.
N.A.
33.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
28
0
0
0
0
0
0
10
0
19
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
0
0
10
0
19
0
0
0
% D
% Glu:
28
0
37
0
0
46
19
10
10
28
0
19
46
0
46
% E
% Phe:
0
0
0
0
0
0
19
10
0
46
0
0
10
0
0
% F
% Gly:
0
19
0
0
55
0
0
0
10
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% H
% Ile:
19
0
0
46
0
0
0
0
0
10
10
0
0
0
0
% I
% Lys:
0
10
46
19
0
0
46
10
19
0
0
46
0
0
0
% K
% Leu:
46
19
0
19
0
55
0
0
46
0
19
10
10
46
19
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% M
% Asn:
0
0
0
10
0
0
0
0
10
0
0
0
19
0
0
% N
% Pro:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% R
% Ser:
0
55
0
0
19
0
0
55
0
0
0
0
0
10
10
% S
% Thr:
0
0
0
0
0
0
0
19
0
0
46
0
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
10
0
19
0
10
19
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _