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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMBS
All Species:
34.55
Human Site:
T145
Identified Species:
76
UniProt:
P08397
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08397
NP_000181.2
361
39330
T145
P
E
K
S
V
V
G
T
S
S
L
R
R
A
A
Chimpanzee
Pan troglodytes
XP_001149046
276
30700
T109
T
V
L
P
P
G
F
T
I
G
A
I
C
K
R
Rhesus Macaque
Macaca mulatta
XP_001101850
361
39314
T145
P
E
K
S
V
V
G
T
S
S
L
R
R
A
A
Dog
Lupus familis
XP_546491
361
39305
T145
P
E
K
S
V
V
G
T
S
S
L
R
R
A
A
Cat
Felis silvestris
Mouse
Mus musculus
P22907
361
39284
T145
P
E
K
S
A
V
G
T
S
S
L
R
R
V
A
Rat
Rattus norvegicus
P19356
361
39343
T145
P
E
K
S
A
V
G
T
S
S
L
R
R
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417846
358
38973
T142
P
E
K
S
V
I
G
T
S
S
L
R
R
A
A
Frog
Xenopus laevis
NP_001089699
351
38279
T135
P
E
K
S
V
I
G
T
S
S
L
R
R
A
A
Zebra Danio
Brachydanio rerio
NP_001019559
360
39395
T142
S
N
K
S
V
I
G
T
S
S
L
R
R
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624261
357
39498
T134
P
E
G
S
V
I
G
T
S
S
L
R
R
S
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781025
324
36125
V135
S
V
L
G
T
S
S
V
R
R
V
A
Q
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.2
99.1
94.1
N.A.
89.4
90.8
N.A.
N.A.
74.2
73.1
70.9
N.A.
N.A.
52.3
N.A.
44.8
Protein Similarity:
100
74.7
99.4
96.6
N.A.
94.1
93.9
N.A.
N.A.
84.7
82.2
80.8
N.A.
N.A.
67.3
N.A.
63.9
P-Site Identity:
100
6.6
100
100
N.A.
86.6
86.6
N.A.
N.A.
93.3
93.3
80
N.A.
N.A.
80
N.A.
0
P-Site Similarity:
100
6.6
100
100
N.A.
86.6
86.6
N.A.
N.A.
100
100
86.6
N.A.
N.A.
93.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
19
0
0
0
0
0
10
10
0
55
82
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
73
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
10
0
10
82
0
0
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
37
0
0
10
0
0
10
0
0
0
% I
% Lys:
0
0
73
0
0
0
0
0
0
0
0
0
0
10
10
% K
% Leu:
0
0
19
0
0
0
0
0
0
0
82
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
73
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
10
10
0
82
82
0
10
% R
% Ser:
19
0
0
82
0
10
10
0
82
82
0
0
0
10
0
% S
% Thr:
10
0
0
0
10
0
0
91
0
0
0
0
0
0
0
% T
% Val:
0
19
0
0
64
46
0
10
0
0
10
0
0
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _