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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMBS
All Species:
32.42
Human Site:
T269
Identified Species:
71.33
UniProt:
P08397
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08397
NP_000181.2
361
39330
T269
S
V
P
V
A
V
H
T
A
M
K
D
G
Q
L
Chimpanzee
Pan troglodytes
XP_001149046
276
30700
G203
M
G
W
H
N
R
V
G
Q
I
L
H
P
E
E
Rhesus Macaque
Macaca mulatta
XP_001101850
361
39314
T269
S
V
P
V
A
V
H
T
A
M
K
D
G
Q
L
Dog
Lupus familis
XP_546491
361
39305
T269
S
V
P
V
A
V
H
T
A
M
K
D
G
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
P22907
361
39284
T269
S
V
P
V
A
V
H
T
V
I
K
D
G
Q
L
Rat
Rattus norvegicus
P19356
361
39343
T269
S
V
P
V
A
V
H
T
V
M
K
D
G
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417846
358
38973
T266
S
V
P
V
A
V
N
T
M
L
K
D
G
Q
L
Frog
Xenopus laevis
NP_001089699
351
38279
T259
S
V
P
V
A
V
S
T
V
V
K
D
S
Q
L
Zebra Danio
Brachydanio rerio
NP_001019559
360
39395
S266
S
V
P
V
A
V
H
S
E
V
K
N
S
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624261
357
39498
S259
S
A
P
V
A
V
S
S
T
L
K
N
K
I
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781025
324
36125
G239
I
R
C
I
A
E
R
G
L
L
K
T
L
E
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.2
99.1
94.1
N.A.
89.4
90.8
N.A.
N.A.
74.2
73.1
70.9
N.A.
N.A.
52.3
N.A.
44.8
Protein Similarity:
100
74.7
99.4
96.6
N.A.
94.1
93.9
N.A.
N.A.
84.7
82.2
80.8
N.A.
N.A.
67.3
N.A.
63.9
P-Site Identity:
100
0
100
100
N.A.
86.6
93.3
N.A.
N.A.
80
73.3
66.6
N.A.
N.A.
46.6
N.A.
13.3
P-Site Similarity:
100
13.3
100
100
N.A.
93.3
93.3
N.A.
N.A.
93.3
80
86.6
N.A.
N.A.
66.6
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
91
0
0
0
28
0
0
0
0
0
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
64
0
0
0
% D
% Glu:
0
0
0
0
0
10
0
0
10
0
0
0
0
19
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
19
0
0
0
0
55
0
10
% G
% His:
0
0
0
10
0
0
55
0
0
0
0
10
0
0
0
% H
% Ile:
10
0
0
10
0
0
0
0
0
19
0
0
0
10
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
91
0
10
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
10
28
10
0
10
0
82
% L
% Met:
10
0
0
0
0
0
0
0
10
37
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
10
0
0
0
0
19
0
0
0
% N
% Pro:
0
0
82
0
0
0
0
0
0
0
0
0
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
10
0
0
0
0
73
0
% Q
% Arg:
0
10
0
0
0
10
10
0
0
0
0
0
0
0
0
% R
% Ser:
82
0
0
0
0
0
19
19
0
0
0
0
19
0
0
% S
% Thr:
0
0
0
0
0
0
0
64
10
0
0
10
0
0
0
% T
% Val:
0
73
0
82
0
82
10
0
28
19
0
0
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _