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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMBS
All Species:
31.82
Human Site:
Y277
Identified Species:
70
UniProt:
P08397
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08397
NP_000181.2
361
39330
Y277
A
M
K
D
G
Q
L
Y
L
T
G
G
V
W
S
Chimpanzee
Pan troglodytes
XP_001149046
276
30700
C211
Q
I
L
H
P
E
E
C
M
Y
A
V
G
Q
G
Rhesus Macaque
Macaca mulatta
XP_001101850
361
39314
Y277
A
M
K
D
G
Q
L
Y
L
T
G
G
V
W
S
Dog
Lupus familis
XP_546491
361
39305
Y277
A
M
K
D
G
Q
L
Y
L
T
G
G
V
W
S
Cat
Felis silvestris
Mouse
Mus musculus
P22907
361
39284
Y277
V
I
K
D
G
Q
L
Y
L
T
G
G
V
W
S
Rat
Rattus norvegicus
P19356
361
39343
Y277
V
M
K
D
G
Q
L
Y
L
T
G
G
V
W
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417846
358
38973
Y274
M
L
K
D
G
Q
L
Y
L
T
G
A
V
Y
S
Frog
Xenopus laevis
NP_001089699
351
38279
Y267
V
V
K
D
S
Q
L
Y
L
T
G
A
V
Y
S
Zebra Danio
Brachydanio rerio
NP_001019559
360
39395
Y274
E
V
K
N
S
Q
L
Y
L
T
G
A
V
Y
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624261
357
39498
T267
T
L
K
N
K
I
L
T
V
T
G
A
V
W
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781025
324
36125
G247
L
L
K
T
L
E
G
G
C
S
A
P
V
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.2
99.1
94.1
N.A.
89.4
90.8
N.A.
N.A.
74.2
73.1
70.9
N.A.
N.A.
52.3
N.A.
44.8
Protein Similarity:
100
74.7
99.4
96.6
N.A.
94.1
93.9
N.A.
N.A.
84.7
82.2
80.8
N.A.
N.A.
67.3
N.A.
63.9
P-Site Identity:
100
0
100
100
N.A.
86.6
93.3
N.A.
N.A.
73.3
66.6
60
N.A.
N.A.
46.6
N.A.
13.3
P-Site Similarity:
100
20
100
100
N.A.
93.3
93.3
N.A.
N.A.
86.6
80
80
N.A.
N.A.
66.6
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
28
0
0
0
0
0
0
0
0
0
19
37
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% C
% Asp:
0
0
0
64
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
10
0
0
0
0
19
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
55
0
10
10
0
0
82
46
10
0
10
% G
% His:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
19
0
0
0
10
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
91
0
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
28
10
0
10
0
82
0
73
0
0
0
0
0
0
% L
% Met:
10
37
0
0
0
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% P
% Gln:
10
0
0
0
0
73
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
19
0
0
0
0
10
0
0
0
0
82
% S
% Thr:
10
0
0
10
0
0
0
10
0
82
0
0
0
0
0
% T
% Val:
28
19
0
0
0
0
0
0
10
0
0
10
91
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
55
0
% W
% Tyr:
0
0
0
0
0
0
0
73
0
10
0
0
0
28
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _