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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDHA1
All Species:
51.52
Human Site:
Y227
Identified Species:
87.18
UniProt:
P08559
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08559
NP_000275.1
390
43296
Y227
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Chimpanzee
Pan troglodytes
A5A6L0
390
43219
Y227
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Rhesus Macaque
Macaca mulatta
XP_001097880
420
46631
Y257
F
I
C
E
N
N
L
Y
A
M
G
T
S
A
E
Dog
Lupus familis
XP_537975
390
43375
Y227
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Cat
Felis silvestris
Mouse
Mus musculus
P35486
390
43213
Y227
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Rat
Rattus norvegicus
P26284
390
43208
Y227
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514100
568
62886
Y405
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Chicken
Gallus gallus
NP_001012562
399
44424
Y234
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Frog
Xenopus laevis
NP_001087610
400
44764
Y237
F
I
C
E
N
N
R
Y
G
M
G
T
S
V
E
Zebra Danio
Brachydanio rerio
NP_998558
393
43722
Y230
F
I
C
E
N
N
K
Y
G
M
G
T
S
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52899
397
43773
F221
F
V
C
E
N
N
G
F
G
M
G
T
T
A
E
Sea Urchin
Strong. purpuratus
XP_001175746
386
42313
Y225
F
V
C
E
N
N
K
Y
G
M
G
T
A
V
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P52901
389
43041
Y227
L
V
C
E
N
N
H
Y
G
M
G
T
A
E
W
Baker's Yeast
Sacchar. cerevisiae
P16387
420
46325
Y247
F
C
C
E
N
N
K
Y
G
M
G
T
A
A
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
79
98.9
N.A.
98.2
97.9
N.A.
63.7
84.7
82
80.1
N.A.
N.A.
N.A.
58.9
59.7
Protein Similarity:
100
99.7
85
99.7
N.A.
99.4
99.2
N.A.
67
91.2
92.2
90
N.A.
N.A.
N.A.
71.7
74.1
P-Site Identity:
100
100
80
100
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
N.A.
N.A.
66.6
80
P-Site Similarity:
100
100
80
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
N.A.
N.A.
86.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.9
46.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
66.4
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
0
0
0
22
22
0
% A
% Cys:
0
8
100
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
100
0
0
0
0
0
0
0
0
0
8
86
% E
% Phe:
93
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
93
0
100
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
72
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
22
0
0
0
0
0
0
0
0
% K
% Leu:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
100
0
0
0
0
0
% M
% Asn:
0
0
0
0
100
100
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
58
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
72
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
100
8
0
0
% T
% Val:
0
22
0
0
0
0
0
0
0
0
0
0
0
72
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _