KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDHA1
All Species:
39.7
Human Site:
Y369
Identified Species:
67.18
UniProt:
P08559
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08559
NP_000275.1
390
43296
Y369
E
E
L
G
Y
H
I
Y
S
S
D
P
P
F
E
Chimpanzee
Pan troglodytes
A5A6L0
390
43219
Y369
E
E
L
G
Y
H
I
Y
S
S
D
P
P
F
E
Rhesus Macaque
Macaca mulatta
XP_001097880
420
46631
Y399
E
E
L
G
H
H
I
Y
S
S
D
S
S
F
E
Dog
Lupus familis
XP_537975
390
43375
Y369
E
E
L
G
Y
H
I
Y
S
S
D
P
P
F
E
Cat
Felis silvestris
Mouse
Mus musculus
P35486
390
43213
Y369
E
E
L
G
Y
H
I
Y
S
S
D
P
P
F
E
Rat
Rattus norvegicus
P26284
390
43208
Y369
E
E
L
G
Y
H
I
Y
S
S
D
P
P
F
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514100
568
62886
Y547
E
E
L
G
Y
H
I
Y
S
R
E
P
P
F
E
Chicken
Gallus gallus
NP_001012562
399
44424
Y376
E
E
L
G
N
H
I
Y
F
N
E
P
P
F
E
Frog
Xenopus laevis
NP_001087610
400
44764
Y379
E
E
I
A
N
H
I
Y
R
N
D
P
T
F
D
Zebra Danio
Brachydanio rerio
NP_998558
393
43722
F372
E
D
L
C
N
H
I
F
Y
N
D
P
P
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52899
397
43773
Y363
E
A
L
Y
A
D
I
Y
H
N
T
P
A
Q
E
Sea Urchin
Strong. purpuratus
XP_001175746
386
42313
Y367
S
E
T
F
T
N
I
Y
A
N
T
A
P
M
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P52901
389
43041
Y368
S
E
L
F
T
N
V
Y
V
K
G
F
G
T
E
Baker's Yeast
Sacchar. cerevisiae
P16387
420
46325
K393
L
F
E
D
V
Y
V
K
G
T
E
T
P
T
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
79
98.9
N.A.
98.2
97.9
N.A.
63.7
84.7
82
80.1
N.A.
N.A.
N.A.
58.9
59.7
Protein Similarity:
100
99.7
85
99.7
N.A.
99.4
99.2
N.A.
67
91.2
92.2
90
N.A.
N.A.
N.A.
71.7
74.1
P-Site Identity:
100
100
80
100
N.A.
100
100
N.A.
86.6
73.3
53.3
53.3
N.A.
N.A.
N.A.
40
26.6
P-Site Similarity:
100
100
86.6
100
N.A.
100
100
N.A.
93.3
86.6
73.3
73.3
N.A.
N.A.
N.A.
46.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.9
46.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
66.4
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
8
0
0
0
8
0
0
8
8
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
8
0
8
0
0
0
0
58
0
0
0
8
% D
% Glu:
79
79
8
0
0
0
0
0
0
0
22
0
0
0
79
% E
% Phe:
0
8
0
15
0
0
0
8
8
0
0
8
0
65
0
% F
% Gly:
0
0
0
58
0
0
0
0
8
0
8
0
8
0
0
% G
% His:
0
0
0
0
8
72
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
86
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% K
% Leu:
8
0
79
0
0
0
0
0
0
0
0
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
22
15
0
0
0
36
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
72
72
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
8
% R
% Ser:
15
0
0
0
0
0
0
0
50
43
0
8
8
0
0
% S
% Thr:
0
0
8
0
15
0
0
0
0
8
15
8
8
15
0
% T
% Val:
0
0
0
0
8
0
15
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
43
8
0
86
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _