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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDHA1 All Species: 50
Human Site: Y82 Identified Species: 84.62
UniProt: P08559 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08559 NP_000275.1 390 43296 Y82 E L K A D Q L Y K Q K I I R G
Chimpanzee Pan troglodytes A5A6L0 390 43219 Y82 E L K A D Q L Y K Q K I I R G
Rhesus Macaque Macaca mulatta XP_001097880 420 46631 Y112 E L K A D Q L Y K Q K F I R G
Dog Lupus familis XP_537975 390 43375 Y82 E L K A D Q L Y K Q K I I R G
Cat Felis silvestris
Mouse Mus musculus P35486 390 43213 Y82 E L K A D Q L Y K Q K I I R G
Rat Rattus norvegicus P26284 390 43208 Y82 E L K A D Q L Y K Q K I I R G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514100 568 62886 Y260 E L K A D Q L Y K Q K I I R G
Chicken Gallus gallus NP_001012562 399 44424 Y89 E L K S D Q L Y K Q K I I R G
Frog Xenopus laevis NP_001087610 400 44764 Y92 E L K S D Q L Y K Q K I I R G
Zebra Danio Brachydanio rerio NP_998558 393 43722 Y85 E L K A D Q L Y K Q K I I R G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52899 397 43773 R82 L Y K E K K I R G F C H L Y S
Sea Urchin Strong. purpuratus XP_001175746 386 42313 Y80 E T A A A T L Y K S K E V R G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P52901 389 43041 Y80 E I A A D S L Y K A K L I R G
Baker's Yeast Sacchar. cerevisiae P16387 420 46325 Y102 E M A C D A L Y K A K K I R G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 79 98.9 N.A. 98.2 97.9 N.A. 63.7 84.7 82 80.1 N.A. N.A. N.A. 58.9 59.7
Protein Similarity: 100 99.7 85 99.7 N.A. 99.4 99.2 N.A. 67 91.2 92.2 90 N.A. N.A. N.A. 71.7 74.1
P-Site Identity: 100 100 93.3 100 N.A. 100 100 N.A. 100 93.3 93.3 100 N.A. N.A. N.A. 6.6 53.3
P-Site Similarity: 100 100 93.3 100 N.A. 100 100 N.A. 100 100 100 100 N.A. N.A. N.A. 26.6 60
Percent
Protein Identity: N.A. N.A. N.A. 48.9 46.9 N.A.
Protein Similarity: N.A. N.A. N.A. 66.4 63.1 N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 60 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 22 72 8 8 0 0 0 15 0 0 0 0 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 0 0 0 86 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 93 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 8 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 93 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 8 0 0 0 0 8 0 0 0 0 65 86 0 0 % I
% Lys: 0 0 79 0 8 8 0 0 93 0 93 8 0 0 0 % K
% Leu: 8 72 0 0 0 0 93 0 0 0 0 8 8 0 0 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 72 0 0 0 72 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 8 0 0 0 0 0 93 0 % R
% Ser: 0 0 0 15 0 8 0 0 0 8 0 0 0 0 8 % S
% Thr: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 93 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _