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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYC1 All Species: 23.33
Human Site: S48 Identified Species: 39.49
UniProt: P08574 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08574 NP_001907.2 325 35390 S48 T P Q A V A L S S K S G L S R
Chimpanzee Pan troglodytes XP_528263 468 49840 S191 T P Q A V A L S S K S G L S R
Rhesus Macaque Macaca mulatta XP_001089897 325 35233 S48 T P Q A V A L S S K S G L S R
Dog Lupus familis XP_532351 325 35262 S48 T S Q A V P L S S K A G P S R
Cat Felis silvestris
Mouse Mus musculus Q9D0M3 325 35309 S48 T P Q A V S L S S K S G P S R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001089640 309 34087 A53 S T L G I L V A G G S G L A F
Zebra Danio Brachydanio rerio NP_001032470 307 33696 T51 T T I G V L T T G G A G L A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647958 307 33746 I48 L I G A L G A I T G G V G A L
Honey Bee Apis mellifera XP_397047 311 34926 V48 V L L A C L G V T A G G I S A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_791551 304 33536 V40 R T K K A A L V T F G A L A A
Poplar Tree Populus trichocarpa XP_002313590 310 33861 R46 S V G M K S L R A F A L F G A
Maize Zea mays NP_001141284 326 35416 S49 T P Q A V S L S S K S G P S R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07143 309 34036 A43 L V T A G V A A A G I T A S T
Red Bread Mold Neurospora crassa P07142 332 36438 P40 S G A A A E S P L R L N I A A
Conservation
Percent
Protein Identity: 100 69.4 94.7 92.3 N.A. 90.7 N.A. N.A. N.A. N.A. 70.4 69.5 N.A. 55 52.9 N.A. 58.4
Protein Similarity: 100 69.4 97.5 94.4 N.A. 94.1 N.A. N.A. N.A. N.A. 82.7 81.8 N.A. 69.8 70.1 N.A. 74.1
P-Site Identity: 100 100 100 73.3 N.A. 86.6 N.A. N.A. N.A. N.A. 20 26.6 N.A. 6.6 20 N.A. 20
P-Site Similarity: 100 100 100 80 N.A. 93.3 N.A. N.A. N.A. N.A. 53.3 46.6 N.A. 26.6 33.3 N.A. 40
Percent
Protein Identity: 50.7 90.4 N.A. N.A. 48 48.4
Protein Similarity: 66.4 93.5 N.A. N.A. 64.3 61.7
P-Site Identity: 6.6 86.6 N.A. N.A. 13.3 6.6
P-Site Similarity: 33.3 93.3 N.A. N.A. 26.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 72 15 29 15 15 15 8 22 8 8 36 29 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 15 0 0 8 0 8 % F
% Gly: 0 8 15 15 8 8 8 0 15 29 22 65 8 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 8 0 8 0 0 8 0 0 8 0 15 0 0 % I
% Lys: 0 0 8 8 8 0 0 0 0 43 0 0 0 0 0 % K
% Leu: 15 8 15 0 8 22 58 0 8 0 8 8 43 0 15 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 0 36 0 0 0 8 0 8 0 0 0 0 22 0 0 % P
% Gln: 0 0 43 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 0 0 0 0 0 8 0 8 0 0 0 0 43 % R
% Ser: 22 8 0 0 0 22 8 43 43 0 43 0 0 58 0 % S
% Thr: 50 22 8 0 0 0 8 8 22 0 0 8 0 0 8 % T
% Val: 8 15 0 0 50 8 8 15 0 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _