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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYP21A2 All Species: 9.09
Human Site: T156 Identified Species: 20
UniProt: P08686 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08686 NP_000491 494 55887 T156 R M R A Q P G T P V A I E E E
Chimpanzee Pan troglodytes Q8HYN1 508 57365 N161 C D M L A T H N G Q S I D I S
Rhesus Macaque Macaca mulatta Q8HYM9 508 57600 N161 C D M L A T H N G Q T I D I S
Dog Lupus familis XP_855593 492 55347 T156 R M R A Q A G T P V A I Q K E
Cat Felis silvestris
Mouse Mus musculus P03940 487 55309 T153 R M R A Q A G T P V A I H K E
Rat Rattus norvegicus Q64562 493 55927 A155 R M R A Q A G A S V A I H K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P12394 508 56966 Q166 C E T L G A A Q D M A L D M A
Frog Xenopus laevis NP_001087443 370 41973 D105 L E T A K Q R D S F I K S Q V
Zebra Danio Brachydanio rerio XP_001919231 534 59970 K195 V L R D Y S G K A V D L S E D
Tiger Blowfish Takifugu rubipres NP_001098706 517 57319 W167 C S I L S E A W T A G L A L D
Fruit Fly Dros. melanogaster Q95078 538 61930 S184 F I G H L H A S D G Q P V D M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 31.2 31.2 77.9 N.A. 71.2 69.6 N.A. N.A. 36 32.1 39.3 33.8 28.2 N.A. N.A. N.A.
Protein Similarity: 100 51.5 51.9 86.8 N.A. 81.7 80.9 N.A. N.A. 54.1 47.1 55.4 50.4 45.5 N.A. N.A. N.A.
P-Site Identity: 100 6.6 6.6 80 N.A. 80 66.6 N.A. N.A. 6.6 6.6 26.6 0 0 N.A. N.A. N.A.
P-Site Similarity: 100 20 13.3 93.3 N.A. 86.6 73.3 N.A. N.A. 26.6 20 46.6 13.3 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 46 19 37 28 10 10 10 46 0 10 0 10 % A
% Cys: 37 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 19 0 10 0 0 0 10 19 0 10 0 28 10 19 % D
% Glu: 0 19 0 0 0 10 0 0 0 0 0 0 10 19 37 % E
% Phe: 10 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % F
% Gly: 0 0 10 0 10 0 46 0 19 10 10 0 0 0 0 % G
% His: 0 0 0 10 0 10 19 0 0 0 0 0 19 0 0 % H
% Ile: 0 10 10 0 0 0 0 0 0 0 10 55 0 19 0 % I
% Lys: 0 0 0 0 10 0 0 10 0 0 0 10 0 28 0 % K
% Leu: 10 10 0 37 10 0 0 0 0 0 0 28 0 10 0 % L
% Met: 0 37 19 0 0 0 0 0 0 10 0 0 0 10 10 % M
% Asn: 0 0 0 0 0 0 0 19 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 10 0 0 28 0 0 10 0 0 0 % P
% Gln: 0 0 0 0 37 10 0 10 0 19 10 0 10 10 0 % Q
% Arg: 37 0 46 0 0 0 10 0 0 0 0 0 0 0 0 % R
% Ser: 0 10 0 0 10 10 0 10 19 0 10 0 19 0 19 % S
% Thr: 0 0 19 0 0 19 0 28 10 0 10 0 0 0 0 % T
% Val: 10 0 0 0 0 0 0 0 0 46 0 0 10 0 10 % V
% Trp: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _