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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IGFBP1
All Species:
12.12
Human Site:
Y181
Identified Species:
26.67
UniProt:
P08833
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08833
NP_000587.1
259
27904
Y181
E
P
C
R
I
E
L
Y
R
V
V
E
S
L
A
Chimpanzee
Pan troglodytes
XP_519083
198
21709
R121
P
C
R
I
E
L
Y
R
V
V
E
S
L
G
K
Rhesus Macaque
Macaca mulatta
XP_001085935
259
27937
Y181
E
P
C
R
I
E
L
Y
R
V
V
E
S
L
T
Dog
Lupus familis
XP_537927
249
26985
L172
K
E
P
C
R
R
E
L
H
E
V
L
A
R
L
Cat
Felis silvestris
Mouse
Mus musculus
P47876
272
29580
Y194
E
P
C
Q
R
E
L
Y
K
V
L
E
R
L
A
Rat
Rattus norvegicus
P21743
272
29665
Y194
E
P
C
Q
R
E
L
Y
K
V
L
E
R
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507702
275
29888
Q197
N
P
C
Q
T
E
L
Q
K
T
L
D
R
L
S
Chicken
Gallus gallus
P49705
311
33520
E221
Q
E
L
D
Q
V
L
E
R
I
S
T
M
R
L
Frog
Xenopus laevis
Q5XHC5
281
30573
E192
L
Q
L
D
Q
V
L
E
R
I
S
G
M
H
L
Zebra Danio
Brachydanio rerio
Q9PTH3
276
30746
E189
Q
E
L
D
Q
V
L
E
R
I
S
K
I
T
F
Tiger Blowfish
Takifugu rubipres
NP_001139534
261
28881
L181
L
A
P
C
R
A
E
L
Q
R
A
L
D
R
L
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.2
92.6
63.3
N.A.
66.1
67.6
N.A.
50.9
32.4
33.4
33.3
31.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
75.6
94.9
74.1
N.A.
78.3
78.3
N.A.
66.1
49.5
51.2
50.7
46.3
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
93.3
6.6
N.A.
66.6
66.6
N.A.
33.3
13.3
13.3
13.3
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
6.6
93.3
20
N.A.
86.6
86.6
N.A.
66.6
26.6
20
33.3
6.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
10
0
0
0
0
10
0
10
0
28
% A
% Cys:
0
10
46
19
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
28
0
0
0
0
0
0
0
10
10
0
0
% D
% Glu:
37
28
0
0
10
46
19
28
0
10
10
37
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% H
% Ile:
0
0
0
10
19
0
0
0
0
28
0
0
10
0
0
% I
% Lys:
10
0
0
0
0
0
0
0
28
0
0
10
0
0
10
% K
% Leu:
19
0
28
0
0
10
73
19
0
0
28
19
10
46
37
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
46
19
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
19
10
0
28
28
0
0
10
10
0
0
0
0
0
0
% Q
% Arg:
0
0
10
19
37
10
0
10
46
10
0
0
28
28
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
28
10
19
0
10
% S
% Thr:
0
0
0
0
10
0
0
0
0
10
0
10
0
10
10
% T
% Val:
0
0
0
0
0
28
0
0
10
46
28
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
37
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _