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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IL6R
All Species:
18.79
Human Site:
T442
Identified Species:
59.05
UniProt:
P08887
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08887
NP_000556.1
468
51548
T442
S
S
L
G
S
D
N
T
S
S
H
N
R
P
D
Chimpanzee
Pan troglodytes
XP_524889
843
90539
T817
S
S
L
G
S
D
N
T
S
S
H
N
R
P
D
Rhesus Macaque
Macaca mulatta
XP_001114404
468
51144
T442
S
S
L
G
S
D
N
T
S
S
H
N
R
P
D
Dog
Lupus familis
XP_855105
468
51305
T442
S
S
L
G
S
D
N
T
S
R
H
S
H
P
D
Cat
Felis silvestris
Mouse
Mus musculus
P22272
460
50436
T434
H
S
S
G
S
D
N
T
V
N
H
S
C
L
G
Rat
Rattus norvegicus
P22273
462
50360
T436
N
S
S
G
T
D
N
T
G
S
H
S
C
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P51641
362
40289
A337
T
K
I
C
D
K
G
A
G
V
G
S
G
A
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001107790
580
65916
H544
P
P
K
H
N
Q
Q
H
F
L
P
V
Q
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
55.2
97.6
75
N.A.
53.8
55.3
N.A.
N.A.
25.2
N.A.
22.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
55.2
97.8
82.4
N.A.
66.2
68.1
N.A.
N.A.
37.6
N.A.
35.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
46.6
46.6
N.A.
N.A.
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
60
66.6
N.A.
N.A.
20
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
13
0
0
0
0
0
13
0
% A
% Cys:
0
0
0
13
0
0
0
0
0
0
0
0
25
0
0
% C
% Asp:
0
0
0
0
13
75
0
0
0
0
0
0
0
0
50
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% E
% Phe:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% F
% Gly:
0
0
0
75
0
0
13
0
25
0
13
0
13
0
25
% G
% His:
13
0
0
13
0
0
0
13
0
0
75
0
13
0
0
% H
% Ile:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
13
13
0
0
13
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
50
0
0
0
0
0
0
13
0
0
0
25
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
13
0
0
0
13
0
75
0
0
13
0
38
0
0
0
% N
% Pro:
13
13
0
0
0
0
0
0
0
0
13
0
0
63
0
% P
% Gln:
0
0
0
0
0
13
13
0
0
0
0
0
13
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
13
0
0
38
0
0
% R
% Ser:
50
75
25
0
63
0
0
0
50
50
0
50
0
0
0
% S
% Thr:
13
0
0
0
13
0
0
75
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
13
13
0
13
0
0
13
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _