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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR1A
All Species:
15.45
Human Site:
S253
Identified Species:
30.91
UniProt:
P08908
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08908
NP_000515.2
422
46107
S253
P
A
P
Q
P
K
K
S
V
N
G
E
S
G
S
Chimpanzee
Pan troglodytes
Q9N298
422
46153
S253
P
A
Q
Q
P
K
K
S
V
N
G
E
S
G
S
Rhesus Macaque
Macaca mulatta
XP_001083407
421
45971
S252
P
T
P
Q
P
K
K
S
V
N
G
E
S
G
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q64264
421
46105
S253
S
A
P
P
P
K
K
S
L
N
G
Q
P
G
S
Rat
Rattus norvegicus
P19327
422
46411
S253
S
A
P
P
P
K
K
S
L
N
G
Q
P
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506318
440
46039
L280
Y
I
P
I
V
L
M
L
V
L
Y
G
R
I
F
Chicken
Gallus gallus
XP_429136
413
45612
K247
S
P
A
A
L
Q
K
K
S
N
G
E
P
G
K
Frog
Xenopus laevis
Q98998
408
45769
K247
S
Q
Q
S
P
K
E
K
Q
R
G
A
Q
Q
E
Zebra Danio
Brachydanio rerio
NP_001116793
398
44671
E249
F
P
R
K
A
N
G
E
V
G
K
T
W
R
R
Tiger Blowfish
Takifugu rubipres
O42385
423
46982
R262
S
P
A
V
F
H
K
R
A
N
G
D
A
V
S
Fruit Fly
Dros. melanogaster
P20905
564
60843
P379
S
P
S
A
P
Q
A
P
P
L
G
H
T
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O02213
455
50851
K275
D
Y
R
K
M
S
I
K
R
A
S
V
E
S
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
98
N.A.
N.A.
87.6
89.8
N.A.
62.9
80
70.1
74.6
71.6
31
N.A.
32.3
N.A.
Protein Similarity:
100
99.5
98.3
N.A.
N.A.
90.7
91.9
N.A.
72.2
86.7
76.7
81.2
81.5
44.6
N.A.
50.3
N.A.
P-Site Identity:
100
93.3
86.6
N.A.
N.A.
66.6
66.6
N.A.
13.3
33.3
20
6.6
26.6
13.3
N.A.
0
N.A.
P-Site Similarity:
100
93.3
86.6
N.A.
N.A.
80
80
N.A.
13.3
40
26.6
13.3
40
26.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
34
17
17
9
0
9
0
9
9
0
9
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% D
% Glu:
0
0
0
0
0
0
9
9
0
0
0
34
9
9
9
% E
% Phe:
9
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
0
0
0
0
0
9
0
0
9
75
9
0
50
9
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
9
0
0
0
% H
% Ile:
0
9
0
9
0
0
9
0
0
0
0
0
0
9
0
% I
% Lys:
0
0
0
17
0
50
59
25
0
0
9
0
0
0
9
% K
% Leu:
0
0
0
0
9
9
0
9
17
17
0
0
0
0
9
% L
% Met:
0
0
0
0
9
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
0
59
0
0
0
0
0
% N
% Pro:
25
34
42
17
59
0
0
9
9
0
0
0
25
0
0
% P
% Gln:
0
9
17
25
0
17
0
0
9
0
0
17
9
9
0
% Q
% Arg:
0
0
17
0
0
0
0
9
9
9
0
0
9
9
9
% R
% Ser:
50
0
9
9
0
9
0
42
9
0
9
0
25
9
42
% S
% Thr:
0
9
0
0
0
0
0
0
0
0
0
9
9
0
0
% T
% Val:
0
0
0
9
9
0
0
0
42
0
0
9
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
9
9
0
0
0
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _