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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRM5
All Species:
22.73
Human Site:
S274
Identified Species:
45.45
UniProt:
P08912
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08912
NP_036257.1
532
60074
S274
N
Q
A
S
W
S
S
S
R
R
S
T
S
T
T
Chimpanzee
Pan troglodytes
Q5IS53
532
59854
S274
N
Q
A
S
R
S
S
S
H
R
S
T
S
I
T
Rhesus Macaque
Macaca mulatta
P56490
532
60122
S274
N
Q
T
S
W
S
S
S
R
R
S
A
S
T
S
Dog
Lupus familis
XP_544597
532
60103
S274
N
E
A
S
W
S
S
S
H
R
S
T
S
T
T
Cat
Felis silvestris
Mouse
Mus musculus
Q920H4
532
60325
S274
N
Q
A
S
W
S
S
S
R
R
S
T
S
T
T
Rat
Rattus norvegicus
P08911
531
60118
S273
N
Q
A
S
W
S
S
S
R
R
S
T
S
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513098
468
51540
K221
A
S
K
S
R
I
K
K
D
K
K
E
P
V
A
Chicken
Gallus gallus
P49578
639
71958
H360
R
R
K
Y
R
R
C
H
F
W
L
T
M
K
S
Frog
Xenopus laevis
P30544
484
54107
K238
C
P
E
T
R
Q
E
K
K
K
P
I
S
S
M
Zebra Danio
Brachydanio rerio
NP_001018639
490
55091
I243
G
D
A
Q
P
Q
K
I
R
S
C
F
G
C
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16395
805
86605
R348
N
D
H
D
T
W
R
R
P
R
S
E
S
S
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U7D5
611
69544
T309
M
K
R
D
V
S
S
T
S
I
I
K
S
S
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
95.8
88.9
N.A.
89
88.5
N.A.
43.4
45.7
42.2
58.8
N.A.
31.6
N.A.
32.4
N.A.
Protein Similarity:
100
96.8
97.5
93
N.A.
93.4
93
N.A.
57.8
59.4
60.7
68.9
N.A.
43.4
N.A.
50.2
N.A.
P-Site Identity:
100
80
80
86.6
N.A.
100
100
N.A.
6.6
6.6
6.6
13.3
N.A.
26.6
N.A.
20
N.A.
P-Site Similarity:
100
80
86.6
93.3
N.A.
100
100
N.A.
13.3
20
33.3
13.3
N.A.
33.3
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
50
0
0
0
0
0
0
0
0
9
0
0
9
% A
% Cys:
9
0
0
0
0
0
9
0
0
0
9
0
0
9
0
% C
% Asp:
0
17
0
17
0
0
0
0
9
0
0
0
0
0
0
% D
% Glu:
0
9
9
0
0
0
9
0
0
0
0
17
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% G
% His:
0
0
9
0
0
0
0
9
17
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
9
0
9
0
9
9
9
0
9
0
% I
% Lys:
0
9
17
0
0
0
17
17
9
17
9
9
0
9
9
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% M
% Asn:
59
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
9
0
0
0
9
0
9
0
9
0
9
% P
% Gln:
0
42
0
9
0
17
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
9
9
0
34
9
9
9
42
59
0
0
0
0
0
% R
% Ser:
0
9
0
59
0
59
59
50
9
9
59
0
75
25
17
% S
% Thr:
0
0
9
9
9
0
0
9
0
0
0
50
0
42
42
% T
% Val:
0
0
0
0
9
0
0
0
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
42
9
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _