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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRM5
All Species:
20
Human Site:
S285
Identified Species:
40
UniProt:
P08912
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08912
NP_036257.1
532
60074
S285
T
S
T
T
G
K
P
S
Q
A
T
G
P
S
A
Chimpanzee
Pan troglodytes
Q5IS53
532
59854
S285
T
S
I
T
G
K
P
S
Q
A
T
G
P
S
T
Rhesus Macaque
Macaca mulatta
P56490
532
60122
S285
A
S
T
S
G
K
P
S
Q
A
T
D
P
S
T
Dog
Lupus familis
XP_544597
532
60103
S285
T
S
T
T
G
K
P
S
Q
A
M
G
P
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q920H4
532
60325
T285
T
S
T
T
G
K
P
T
Q
A
T
D
L
S
A
Rat
Rattus norvegicus
P08911
531
60118
T284
T
S
T
T
G
K
T
T
Q
A
T
D
L
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513098
468
51540
P232
E
P
V
A
N
Q
D
P
V
S
P
S
L
V
H
Chicken
Gallus gallus
P49578
639
71958
N371
T
M
K
S
W
E
P
N
T
D
Q
G
D
Q
E
Frog
Xenopus laevis
P30544
484
54107
L249
I
S
S
M
K
S
L
L
I
K
Q
T
K
N
I
Zebra Danio
Brachydanio rerio
NP_001018639
490
55091
N254
F
G
C
K
H
V
S
N
T
S
R
T
Q
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16395
805
86605
S359
E
S
S
P
D
A
E
S
V
Y
M
T
N
M
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U7D5
611
69544
K320
K
S
S
G
S
M
R
K
K
N
N
Q
D
G
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
95.8
88.9
N.A.
89
88.5
N.A.
43.4
45.7
42.2
58.8
N.A.
31.6
N.A.
32.4
N.A.
Protein Similarity:
100
96.8
97.5
93
N.A.
93.4
93
N.A.
57.8
59.4
60.7
68.9
N.A.
43.4
N.A.
50.2
N.A.
P-Site Identity:
100
86.6
73.3
86.6
N.A.
80
73.3
N.A.
0
20
6.6
0
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
86.6
80
86.6
N.A.
86.6
80
N.A.
13.3
40
20
20
N.A.
20
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
0
9
0
0
0
50
0
0
0
9
25
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
0
9
0
0
9
0
25
17
0
0
% D
% Glu:
17
0
0
0
0
9
9
0
0
0
0
0
0
0
9
% E
% Phe:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
9
50
0
0
0
0
0
0
34
0
9
0
% G
% His:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
9
0
9
0
0
0
0
0
9
0
0
0
0
0
9
% I
% Lys:
9
0
9
9
9
50
0
9
9
9
0
0
9
0
0
% K
% Leu:
0
0
0
0
0
0
9
9
0
0
0
0
25
0
9
% L
% Met:
0
9
0
9
0
9
0
0
0
0
17
0
0
9
0
% M
% Asn:
0
0
0
0
9
0
0
17
0
9
9
0
9
9
0
% N
% Pro:
0
9
0
9
0
0
50
9
0
0
9
0
34
0
0
% P
% Gln:
0
0
0
0
0
9
0
0
50
0
17
9
9
9
0
% Q
% Arg:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% R
% Ser:
0
75
25
17
9
9
9
42
0
17
0
9
0
50
0
% S
% Thr:
50
0
42
42
0
0
9
17
17
0
42
25
0
0
25
% T
% Val:
0
0
9
0
0
9
0
0
17
0
0
0
0
9
9
% V
% Trp:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _