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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHRM5 All Species: 22.73
Human Site: S59 Identified Species: 45.45
UniProt: P08912 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08912 NP_036257.1 532 60074 S59 M I S F K V N S Q L K T V N N
Chimpanzee Pan troglodytes Q5IS53 532 59854 S59 M I S F K V N S Q L K T V N N
Rhesus Macaque Macaca mulatta P56490 532 60122 S59 M I S F K V N S Q L K T V N N
Dog Lupus familis XP_544597 532 60103 S59 M I S F K V N S Q L K S V N N
Cat Felis silvestris
Mouse Mus musculus Q920H4 532 60325 S59 M I S F K V N S Q L K T V N N
Rat Rattus norvegicus P08911 531 60118 S58 M I S F K V N S Q L K T V N N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513098 468 51540
Chicken Gallus gallus P49578 639 71958 K145 I V S F K V N K Q L K T V N N
Frog Xenopus laevis P30544 484 54107 E23 S I D E T I V E I P G K Y Q T
Zebra Danio Brachydanio rerio NP_001018639 490 55091 I28 S L W E V I A I A T V S A I V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P16395 805 86605 K133 M I S F K I D K Q L Q T I S N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9U7D5 611 69544 K94 M V S F K I D K Q L Q T I S N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 95.8 88.9 N.A. 89 88.5 N.A. 43.4 45.7 42.2 58.8 N.A. 31.6 N.A. 32.4 N.A.
Protein Similarity: 100 96.8 97.5 93 N.A. 93.4 93 N.A. 57.8 59.4 60.7 68.9 N.A. 43.4 N.A. 50.2 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 100 100 N.A. 0 80 6.6 0 N.A. 60 N.A. 53.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 93.3 13.3 20 N.A. 93.3 N.A. 93.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 9 0 9 0 0 0 9 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 17 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 17 0 0 0 9 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 75 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 67 0 0 0 34 0 9 9 0 0 0 17 9 0 % I
% Lys: 0 0 0 0 75 0 0 25 0 0 59 9 0 0 0 % K
% Leu: 0 9 0 0 0 0 0 0 0 75 0 0 0 0 0 % L
% Met: 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 59 0 0 0 0 0 0 59 75 % N
% Pro: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 75 0 17 0 0 9 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 17 0 75 0 0 0 0 50 0 0 0 17 0 17 0 % S
% Thr: 0 0 0 0 9 0 0 0 0 9 0 67 0 0 9 % T
% Val: 0 17 0 0 9 59 9 0 0 0 9 0 59 0 9 % V
% Trp: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _