Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGB1 All Species: 14.55
Human Site: S181 Identified Species: 24.62
UniProt: P09429 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.38
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P09429 NP_002119.1 215 24894 S181 G V V K A E K S K K K K E E E
Chimpanzee Pan troglodytes Q9N1Q7 215 24747 A207 A T K R V V K A E K S K K K K
Rhesus Macaque Macaca mulatta XP_001102554 215 24881 S181 G V V K A E K S K K K K E E E
Dog Lupus familis XP_543194 210 24144 E192 N E P E D E E E E E E E E E D
Cat Felis silvestris
Mouse Mus musculus P30681 210 24143 E192 N E P E D E E E E E E E E E E
Rat Rattus norvegicus P63159 215 24875 S181 G V V K A E K S K K K K E E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508702 215 24789 S181 G V A K A E K S K K K K E E E
Chicken Gallus gallus P26584 207 23809 P187 G S K K K A E P E E E E E E E
Frog Xenopus laevis NP_001080836 211 24437 A181 A P A K P E K A K K K E E D D
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24537 393 44916 L376 A Q Q Q H Q Q L E E Q H D D D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09390 235 27301 D218 G M D H Y D D D N I H H V V H
Sea Urchin Strong. purpuratus P40644 200 22815 S184 Q V K E S S S S S S S D S S S
Poplar Tree Populus trichocarpa
Maize Zea mays P27347 157 17127 E150 E D D E E G S E E D E D D D E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11632 93 10784 E86 K R Y E S E K E L Y N A T L A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 69.3 99 80.9 N.A. 80.4 99 N.A. 93.9 78.1 85.5 N.A. N.A. 26.7 N.A. 34 47.9
Protein Similarity: 100 73.4 99.5 87.9 N.A. 87.4 100 N.A. 98.1 85.5 93.4 N.A. N.A. 38.9 N.A. 50.6 60
P-Site Identity: 100 20 100 20 N.A. 26.6 100 N.A. 93.3 33.3 46.6 N.A. N.A. 0 N.A. 6.6 13.3
P-Site Similarity: 100 60 100 66.6 N.A. 66.6 100 N.A. 93.3 66.6 73.3 N.A. N.A. 60 N.A. 20 26.6
Percent
Protein Identity: N.A. 35.3 N.A. N.A. 20 N.A.
Protein Similarity: N.A. 48.3 N.A. N.A. 29.3 N.A.
P-Site Identity: N.A. 6.6 N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. 40 N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 0 15 0 29 8 0 15 0 0 0 8 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 15 0 15 8 8 8 0 8 0 15 15 22 22 % D
% Glu: 8 15 0 36 8 58 22 29 43 29 29 29 58 50 50 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 43 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 8 8 0 0 0 0 0 8 15 0 0 8 % H
% Ile: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % I
% Lys: 8 0 22 43 8 0 50 0 36 43 36 36 8 8 8 % K
% Leu: 0 0 0 0 0 0 0 8 8 0 0 0 0 8 0 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 15 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % N
% Pro: 0 8 15 0 8 0 0 8 0 0 0 0 0 0 0 % P
% Gln: 8 8 8 8 0 8 8 0 0 0 8 0 0 0 0 % Q
% Arg: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 8 0 0 15 8 15 36 8 8 15 0 8 8 8 % S
% Thr: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % T
% Val: 0 36 22 0 8 8 0 0 0 0 0 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _