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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB1
All Species:
36.36
Human Site:
T22
Identified Species:
61.54
UniProt:
P09429
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09429
NP_002119.1
215
24894
T22
S
Y
A
F
F
V
Q
T
C
R
E
E
H
K
K
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
D51
S
H
N
N
T
L
V
D
P
C
E
E
H
K
K
Rhesus Macaque
Macaca mulatta
XP_001102554
215
24881
T22
S
Y
A
F
F
V
Q
T
C
R
E
E
H
K
K
Dog
Lupus familis
XP_543194
210
24144
T22
S
Y
A
F
F
V
Q
T
C
R
E
E
H
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P30681
210
24143
T22
S
Y
A
F
F
V
Q
T
C
R
E
E
H
K
K
Rat
Rattus norvegicus
P63159
215
24875
T22
S
Y
A
F
F
V
Q
T
C
R
E
E
H
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508702
215
24789
T22
S
Y
A
F
F
V
Q
T
C
R
E
E
H
K
K
Chicken
Gallus gallus
P26584
207
23809
T22
S
Y
A
Y
F
V
Q
T
C
R
E
E
H
K
K
Frog
Xenopus laevis
NP_001080836
211
24437
T22
S
Y
A
Y
F
V
Q
T
C
R
E
E
H
K
K
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24537
393
44916
T192
A
Y
A
Y
F
V
Q
T
C
R
E
E
H
K
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
M58
P
Y
G
F
F
V
K
M
C
Y
E
E
H
K
K
Sea Urchin
Strong. purpuratus
P40644
200
22815
D24
A
Y
A
Y
F
V
Q
D
S
R
A
E
H
G
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P27347
157
17127
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11632
93
10784
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69.3
99
80.9
N.A.
80.4
99
N.A.
93.9
78.1
85.5
N.A.
N.A.
26.7
N.A.
34
47.9
Protein Similarity:
100
73.4
99.5
87.9
N.A.
87.4
100
N.A.
98.1
85.5
93.4
N.A.
N.A.
38.9
N.A.
50.6
60
P-Site Identity:
100
40
100
100
N.A.
100
100
N.A.
100
93.3
93.3
N.A.
N.A.
86.6
N.A.
66.6
60
P-Site Similarity:
100
53.3
100
100
N.A.
100
100
N.A.
100
100
100
N.A.
N.A.
100
N.A.
73.3
73.3
Percent
Protein Identity:
N.A.
35.3
N.A.
N.A.
20
N.A.
Protein Similarity:
N.A.
48.3
N.A.
N.A.
29.3
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
0
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
72
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
72
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
79
86
0
0
0
% E
% Phe:
0
0
0
50
79
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
86
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
8
0
0
0
0
0
0
79
86
% K
% Leu:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
72
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
72
0
0
0
0
0
% R
% Ser:
65
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
8
0
0
65
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
79
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
79
0
29
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _